1,2,3-三氮唑衍生物的合成及其抑制幽门螺杆菌活性研究

摘要

Fifteen unknown 1-（2-（4-subsitituted）phenyloxyethyl）-1,2,3-triazole derivatives winthout recorded report were synthesized,their structures were confirmed by NMR,IR,and MS.Synthetic conditions were discussed,the optimum reaction conditions were obtained as follows： n（RX）：n（NaN3）=1：3,reaction temperature 65℃.The preliminary results against Helicobacter pylori（HP） indicated that four compounds 4c,5d,5k and 5l could show a high antibacterial activity against HP.%设计并合成了15个未曾见文献报道的1-（2-（4-取代）苯氧乙基）-1H-1,2,3-三氮唑衍生物,并通过NMR、IR、MS确认了它们的结构.对合成条件进行了探讨,得出了叠氮化的最佳合成条件：卤代烃/叠氮化钠摩尔比为1：1.5,反应温度为65℃,幽门螺旋杆菌（HP）体外抑制活性测试结果表明,化合物4c、5d、5k、5l对1 6株HP表现出一定的抑制活性.