环糊精聚合物功能化的Fe3O4磁性纳米粒子作为药物载体的研究

摘要

采用一步反应法制备得到了交联羧甲基-β-环糊精聚合物功能化的Fe3 O4磁性纳米粒子(CDP-MNPs),选取抗癌药物喜树碱(CPT)作为模型药物,运用荧光光谱法研究了CDP-MNPs的载药性能和释放行为,并探讨了pH对CDP-MNPs药物释放性能的影响.此外,细胞毒性试验表明,CDP-MNPs具有良好的生物相容性,而CPT@CDP-MNPs可以明显杀死HepG2肝癌细胞.%Carboxymethyl-β-cyclodextrin polymer modified magnetic nanoparticles CDP-MNPs were prepared with a one-step method by anchoring cyclodextrin polymer onto the surface of Fe3O4 superparamagnetic nanopartieles (MNPs).The loading and release behaviors of CDP-MNPs as drug carrier were evaluated by fluorescence spectroscopy method using camptothecin (CPT) as model drugs.The pH effects on CDP-MNPs for drug releasing were investigated.In addition,the MTT assays showed CDP-MNPs had excellent biocompatibility,and the CPT@CDP-MNPs decreased the relative cellular viability of HepG2 cells evidently.