双相障碍与脑源性神经营养因子信号通路研究进展

摘要

Brain derived neurotrophic factor (BDNF) can prevent neurons from death, promote growth, development and differentiation of neurons, enhance restoration and regeneration of neurons, and reinforce signal transduction among synapses. It has been revealed that BDNF is related to the pathogenesis and treatment of bipolar disorder. The downstream signaling pathway of BDNF changes accordingly in bipolar disorder, and the mechanism of mood stabilizers in treatment of bipolar disorder may be related to the up-regulation of BDNF expression by mediating factors in the downstream signaling pathway of BDNF. In this paper, the relationship between the pathogenesis and treatment of bipolar disorder and signaling pathway of BDNF is reviewed.%脑源性神经营养因子(BDNF)具有防止神经元死亡的功能,可促进神经元生长、发育和分化,促进神经元修复和再生,加强突触间信号的转导.研究表明:BDNF与双相障碍的发病和治疗有关,双相障碍患者脑内BDNF下游信号转导通路也发生相应变化,而心境稳定剂的治疗机制可能与调控BDNF下游信号转导通路中各因子而上调BDNF表达有关.该文就双相障碍的发病和治疗与BDNF信号通路关系的研究进展进行综述.