女性月经失调患者甲状腺功能分析

摘要

目的 了解秦皇岛地区女性月经失调与甲状腺功能的关系. 方法 选取2009年6月至2012年6月在秦皇岛市妇幼保健院生殖医学科就诊的1 92例月经失调女性作为病例组,年龄22～40岁,平均年龄(30±5.92)岁；同时选取在我院体检中心体检健康女性200例为对照组,年龄20～45岁,平均年龄(29±4.89)岁.通过化学发光法检测两组人群的甲状腺功能,比较两组的甲状腺激素和促甲状腺激素水平,分析甲状腺功能紊乱对女性月经的影响. 结果 病例组的甲状腺激素、促甲状腺激素与对照组相比差异无统计学意义(P＞0.05).病例组中甲状腺功能减退(甲减)的比例为10.42％,亚临床型甲减的比例为4.69％,甲状腺功能亢进(甲亢)的比例为6.25％,亚临床型甲亢的比例为3.62％.对照组中甲减的比例为2.00％,亚临床甲减的比例为3.00％,甲亢的比例为2.50％,亚临床甲亢的比例为3.00％.两组比较,病例组中上述4种甲状腺疾病的发生率均高于对照组,其中两组甲减的发生率存在统计学差异(P＜0.05),另外3种甲状腺疾病发生率无统计学差异(P＞0.05).甲减和亚临床甲减患者月经失调的类型主要为月经稀发；而甲亢和亚临床甲亢患者月经失调的类型主要为月经过少. 结论 甲状腺功能紊乱可引起月经失调,检测月经失调女性的甲状腺功能对明确病因具有一定的临床指导意义.%Objective: To analyze the relationship between thyroid function and menstrual disorder.rnMethods: One hundred and ninety two patients with menstrual disorder were recruited as the pathological group from outpatients of the Reproductive Medicine from June 2009 to June 2012. At the same time, two hundreds health women with normal menstruation were selected as the control group. The levels of thyroid hormone and thyroid stimulating hormone were detected and compared between the two groups. The influence of thyroid function to menstrual disorder was analyzed.rnResults: The levels of thyroid hormone and thyroid stimulating hormone in serum were not significantly different between pathological group and control group (P>0. 05). In the pathological group, the proportions of hypothyroidism, subclinical hypothyroidism, hyperthyroidism, and subclinical hyperthyroidism were 10.42%, 4.69%, 6.25% and 3.62% respectively. In the control group, the proportions of hypothyroidism, subclinical hypothyroidism, hyperthyroidism, and subclinical hyperthyroidism were 2.00%, 3.00%, 2.50% 3.00% respectively. The incidences of the thyroid diseases in the pathological group were higher than those in the control group, but there were no significant differences (P>0. 05) except the incidence of hypothyroidism (P<0. 05). The main type ofrnmenstrual disorders was oligomenorrhea in the patients with hypothyroidism and subclinical hypothyroidism, and hypomenorrhea in the patients with hyperthyroidism and subclinical hyperthyroidism.rnConclusions: Thyroid dysfunction could cause menstrual disorders. The detection of thyroid function in the menstrual disorder women could offer some cues in diagnosis.