乙型肝炎病毒对辅助生殖患者胚胎发育的影响

摘要

目的 探讨乙型肝炎病毒(HBV)感染对胚胎发育的影响,为HBV阳性患者改善周期结局,提供更多理论依据.方法 收集从2012年1月至2016年9月来我院就诊的4 301个ART周期病理资料,按是否HBV感染分为三组,A组:男方和女方均HBV阴性(n=3 940);B组:女方HBV阳性而男方阴性(n=195);C组:女方HBV阴性而男方阳性(n=166),比较三组的胚胎受精率、卵裂率、可移植胚胎率、优质胚胎率及妊娠率.结果 (1)ART患者B组妊娠率明显低于A组(39.8% vs 52.6%),且差异具有统计学意义(P<0.05);(2)IVF周期中B和C组的受精率、卵裂率、可移植胚胎率及优质胚胎率与A组相比,差异无统计学意义;(3)ICSI周期中C组受精率明显低于A组(75.1% vs 83.5%),差异有统计学意义(P<0.05).结论 HBV可能通过影响胚胎着床或者子宫内膜而影响周期结局.%Objective:To investigate the effect of Hepatitis B virus (HBV) infection on embryo development,and provide more theoretical basis for improving the outcome in assisted reproductive technique (ART) in HBV positive patients.Methods:The ART 4 301 cycles in ART patients with pathological data in our hospital from January 2012 to September 2016 were collected.The ART cycles were divided into three groups according to whether HBV infection:Both of husband and wife were negative for HBV in group A(n=3 940);The wife was HBV positive while husband was negative in group B(n=195);The woman HBV negative while husband was positive in group C(n=166).The fertilization rate,cleavage rate,transplantable embryo rate,high quality embryo rate and pregnancy rate were compared among the three groups.Results:The pregnancy rate of group B was significantly lower than that of group A((39.8% vs 52.6%)(P<0.05).The fertilization rate,cleavage rate,transferred embryo rate and high quality embryos rate in group B or group C were not different with group A.The fertilization rate of ICSI cycle in group C with was significantly lower than that in the group A(P<0.01).Conclusions:HBV infection has a negative effect on the clinical outcome of assisted reproductive technology.