ACS患者中测定血清炎性细胞因子水平变化的临床应用分析

摘要

Objective To evaluate analysis of clinical application on determining serum inflammatory cytokines levels in patients with acute coronary syndrome ( ACS ). Methods The levels of interleukin-1β( IL-1β), interleukin-6(IL-6), interleukin-8 ( IL-8 ), high-sensitive C-reaction protein ( hs-CRP ) ( with high-sensilive enzyme immunoassay ) and tumor necrosis factor-α ( TNF-α ) ( with radioimmunoassay ) in serum were determined in 112 patients with ACS, 32 patients with stable angina pectoris (SAP) and 42 normal controls as well as did compared analysis. Results The serum IL-1β, IL-6, IL-8, TNF-α and hs-CRP levels in 112 patients with ACS were obviously higher than those in 42 controls( P all〈 0.01 ), but in 32 patients with stable angina pectoris ( SAP ) were no significantly than those in 42 controls ( P all 〉 0.05 ), serum hs-CRP level was increased only ( P〈 0.05 ).The sertm IL-1β, IL-6, IL-8, TNF-α and hs-CRP levels in 46 patients with acute myocandial infraction ( AMI ) were prominently higher than those in 66 patients with unstable angina pectoris ( UAP ) and in 32 patients with SAP. The serum IL-1β, IL-6, IL-8,TNF-α and hs-CRP levels with advanced degree SAP, UAP and AMI were increased. Conclusion In the severity of the patients with SAP, UAP, AMI, the determination of serum inflammatory eytokines level were a good and important index, so that it was referential for heart coronary events happened.%目的:为了探讨急性冠状动脉综合征(ACS)患者测定血清炎性细胞因子水平变化的临床应用分析.方法:采用放射免疫分析和超敏酶免疫分析112例ACS患者,其中46例急性心肌梗死(AMI)患者,66例为不稳定型心绞痛(UAP)患者和32例稳定型心绞痛(SAP)患者血清IL-1β、IL-6、IL-8、TNF-α和hs-CRP水平并与42例正常对照组进行了比较.结果:112例ACS患者中,46例AMI患者和66例UAP患者血清IL-1β、IL-6、IL-8、TNF-α和hs-CRP水平较对照组显著增高(P均＜0.01);而32例SAP患者较对照组血清IL-1β、IL-6、IL-8、TNF-α无明显差异(P均＞0.05),而血清hs-CRP水平明显增高(P＜0.05);46例AMI患者血清IL-1β、IL-6、IL-8、TNF-α和hs-CRP水平较66例UAP患者和32例SAP患者显著增高(P均＜0.01);66例UAP患者较32例SAP患者亦显著增高(P均＜0.01);而且随SAP、UAP、AMI患者疾病的严重程度而增高.结论:血清IL-1β、IL-6、IL-8、TNF-α和hs-CRP的测定是判断ACS严重程度的重要指标,并可预示心血管事件的发生.