e抗原阳性慢性乙型肝炎患者血清HBV-DNA与HBsAg、HBeAg的相关性分析

摘要

Objective To study the relationship among hepatitis B virus DNA ( HBV-DNA) , HBsAg and HBeAg levels in chronic hepatitis B patients with e antigen positive. Methods HBV-DNA, HBsAg and HBeAg levels of 319 chronic hepatitis B patients with e antigen positive were detected by realtime-PCR, tune-resolved fluoroimmuiioassay (TrFEA) and auto biochemistry analyzer respec-tively. The data was analyzed by SPSS software. Results There was highly correlation (r =0.514, P50岁组的HBV-DNA、HBsAg 及HBeAg值皆高于年龄 <30岁组 (P<0.001).结论 e抗原阳性慢性乙型肝炎患者血清中HBV-DNA载量与HBsAg、HBeAg定量水平皆有相关性,其中与HBsAg相关性更佳.