骨生化指标联检在骨质疏松诊疗中的临床意义

摘要

目的:探讨25-羟基维生素D(25-OH-VD)与抗酒石酸酸性磷酸酶(TRACP-5b)联检在骨质疏松诊疗中的意义.方法:使用英国IDS公司的试剂盒,采用酶联免疫法(ELISA),对328例中老年患者血清做25-OH-VD与TRACP-5b的检测及分析.结果:25-OH-VD指标均偏低,男性(16.18±6.77)ng/ml,女性(15.16±7.87)ng/ml,男女间差异无统计学意义(P＞0.05)；TRACP-5b水平女性高于男性,女性(5.71±2.46)u/L,男性(4.98±1.61)u/L,差异具有统计学意义(P＜0.05).25-OH-VD与TRACP-5b两项指标比较,相关系数?=-0.121,两指标呈负相关,有统计学意义(P＜0.05).结论:25-OH-VD与TRACP-5b联检对骨质疏松诊疗具有重要的参考价值.%Objective To discuss the meaning of 25-OH-VD and TRACP-5b insepction in the diagnosis and treatment of osteoporosis. Methods Use English ISD companys reagent kit on 328 elderly patients serum 25-OH-VD, TRACP-5b detection by EIISA. Analysis was made based on the results. Results The concentration of 25-OH-VD were on the low levels, male 15. 18 ±6. 77ng/ml, female 15. 16 ±7.87ng/ml. Male and female had no difference (P>0.05); The level of TRACP-5b in female group was statistically higher than that in male group. The former was 5.71 ±2.46u/ml, the latter was 4.98 ±1.61u/ml, and the difference was statistically significant (P <0.05). The two indicators of 25-OH-VD and TRACP-5b were compared, with statistical significance (P <0. 05 ), correlation coefficient = -0.121 ,two negatively related. Conclusion 25-OH-VD and TRACP-5b inspection on osteoporosis diagnosis has important reference value.