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Characteristics of bone biochemical indices in predicting secondary osteoporotic fracture after intertrochanteric fracture in elderly women

机译:骨生化指标预测老年女性转子间骨折继发骨质疏松性骨折的特征

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Summary Background This study aimed to explore the characteristics of bone biochemical indices, including bone mineral density (BMD), metabolic markers in elderly women with osteoporotic intertrochanteric fracture and their relevance in secondary fracture. Methods The standard for follow-up from 58 elderly women was established to analyse the BMD in the injured hip, healthy hip, and the vertebra at 1 week and 12 months after fracture. The serum levels of total procollagen type N-terminal propeptide (tPINP) and the age-related type I cross linked C-telopeptide (β-CTX) were recorded and compared between those patients with and without secondary fractures within 12 months. Results Twelve months after fracture, the serum levels of tPINP and β-CTX were significantly higher than the baseline values ( p ?
机译:发明背景本研究旨在探讨骨生化指标的特征,包括骨质疏松性转子间骨折的老年妇女的骨矿物质密度(BMD),代谢标志物及其与继发性骨折的相关性。方法建立58例老年妇女的随访标准,以分析骨折后1周和12个月时髋部,健康髋部和椎骨的骨密度。记录并比较12个月内有无继发性骨折的患者的血清总胶原蛋白N末端前肽(tPINP)和年龄相关的I型交联的C端肽(β-CTX)的血清水平。结果骨折后十二个月,tPINP和β-CTX的血清水平显着高于基线值(p≤0.01)。继发性骨折患者的tPINP基线显着低于其他无继发性骨折的患者(p <0.01)。 β-CTX基线明显高于无继发性骨折的基线(p <0.01)。三个时期的BMD值无明显差异。结论血清tPINP和β-CTX较早具有重要价值,更能反映人体骨骼更新状况。同时,他们可以结合较低的BMD更准确地预测后续的骨折风险。本文的翻译潜力除了BMD以外,还可以通过骨生化指标准确测量骨的微观结构和重塑水平。这项研究的主要目的是探讨12个月内单侧股骨粗隆间骨折的老年妇女的骨密度和骨生化指标的变化。同时,为了更好地获得骨重塑水平并更准确地预测继发性骨质疏松性骨折的风险,在随访期间收集或不进行继发性骨质疏松性骨折的这些患者的骨生化指标并分别进行比较。

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