聚氧化乙烯水凝胶膜的辐射接枝研究

摘要

为了得到一种理想的水凝胶伤口敷料,研究了应用电子束辐射接枝了不同比例聚乙烯醇(PVA)的聚氧化乙烯(PEO)水凝胶膜的制备和该膜的理化特性.实验结果显示,PEO接枝水凝胶膜的凝胶分数主要依赖于辐射剂量和聚合物浓度.而其溶胀度与辐射剂量聚合物的浓度,混合比例和分子量密切相关.该膜的抗张强度和断裂伸长率则明显地依赖于辐射剂量和聚合物的混合比例.实验发现,比例为7:3的20wt% PEO E-30接枝水凝胶膜与其它PEO接枝水凝胶膜和单纯PEO E-30水凝胶膜相比具有较好的理化特性,例如韧性,较少气泡,适度的凝胶分数,溶胀度和断裂伸长率,尤其它的较高的抗张强度.实验结果表明,PVA在辐射接枝后能够通过降低PEO水凝胶膜的溶胀度而改善PEO水凝胶膜的机械强度.%In order to obtain a more ideal hydrogel wound dressing, PEO grafthydrogel films formed by electron beam(EB) irradiation of the aqueous solutions ofpoly(ethylene oxide) (PEO)incorporated with poly(vinyl alcohol) (PVA) at differentratio wereprepared, and their physiochemical properties were investigated asafunction of production factors combination. The experimentalresults showed that gelfraction of the PEO graft hydrogel filmsdepended mainly on irradiation dose andconcentration of the polymers.Their degree of swelling was intimately related toirradiationdose, concentration, blending ratio and molecular weight of thepolymers.Their tensile strength and elongation at breakwere obviously dependent onirradiation doseand blending ratio of the polymers. It is found that a new PEOE-30graft hydrogel film of 20 wt% at a ratio of 7:3 has betterphysiochemicalproperties such as flexibility, moderate gel fraction, degree of swelling andelongation at break, especially its higher tensile strength than other PEO grafthydrogel films or pure PEO E-30 hydrogel film. These results indicated that PVA canimprove the mechanical strength of the PEO E-30 hydrogel film through reducing thedegree of swelling of the PEO E-30 hydrogel film after the irradiation graft.