Objective Understand the situation of syphilis infection of maternal and neonatal in Longgang area in Shenzhen , to provide basis for the local health authorities to formulate policies .Methods Toluidine red unheated serum test ( TRUST) was used to detect syphilis as screening for the maternal those who did the check -up and delivery in Longgang central hospital from January 2011 to December 2014.All the screening positive serum samples were confirmed by treponema pallidum agglutination test ( TPPA ) , and the maternal with positive result were filing and followed up .The specimens of the neonatal whose mothers were confirmed with syphilis infection were sent to Shenzhen chronic dispensary to detect 19s-IgM.Results 29625 cases of the maternal were detected syphilis in Longgang area in Shenzhen city from January 2011 to December 2014, in which has 88 cases of syphilis positive result and the positive rate was 0.30%(88/29625).In the demographic characteristics of 88 cases of the maternal with syphilis infection , the group of non -residence in Shenzhen accounts for 96.6%, the 25-30 year-old group accounts for 43.2%, unemployed group accounts for 81.8%, and the group of the education level of junior high school or less accounts for 84.1%.39 cases of maternal with syphilis infection did the delivery in our hospital .There are four cases of neonatal 19s -IgM positive and the positive rate was 10.2%(4/39), including three cases of maternal with syphilis infection did not receive the standard treatment for syphilis during pregnancy and that one case of maternal with syphilis infection got the treatment during pregnancy , but the TRUST titer was up to 1:128, and the treatment was ineffective . Conclusions Syphilis infection situation of the maternal in Longgang area is at a low level .There is a high risk of syphilis vertical transmission for maternal with syphilis infection .As for syphilis, pregnant women should do the early screening , early diagnosis and early treatment to reduce the risk of congenital syphilis .%目的：了解深圳市龙岗地区孕产妇及新生儿梅毒感染情况，为本地区卫生主管部门制定政策提供依据。方法对2011年1月至2014年12月到龙岗中心医院进行产检和分娩的孕产妇采用甲苯胺红不加热血清试验（ TRUST）进行筛查，筛查阳性血清采用梅毒螺旋体明胶颗粒凝集法（ TPPA）进行确诊，对阳性孕产妇进行建档和随访；梅毒产妇分娩新生儿标本送往深圳市慢性病防治所进行19s－IgM检测。结果深圳市龙岗区2011年1月至2014年12月共检测孕产妇29625例，梅毒阳性88例，阳性率为0．30％（88／29625）；在88例梅毒孕产妇的人口学特征中，非深户占96．6％，25～30岁占43．2％，无业占81．8％，初中文化以下占84．1％。在我院分娩的梅毒产妇有39例，其中新生儿血清19s－IgM阳性4例，阳性率10．2％（4／39），其中有3例梅毒产妇在妊娠期间未接受梅毒规范化治疗，1例梅毒产妇在妊娠期间接受治疗，但是TRUST滴度高达1∶128，治疗效果欠佳。结论龙岗地区孕产妇梅毒感染情况处于较低水平，梅毒产妇发生胎传梅毒风险较高；对于梅毒，孕妇要早筛查、早诊断和早治疗，减少发生先天性梅毒的风险。
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