α干扰素对类风湿关节炎患儿 CD4＋、CD8＋T细胞CD69、CD25表达影响研究

摘要

Objective To investigate expression of the α-interferon on rheumatoid arthritis in children CD69 , CD25 of CD4+, CD8+T cells.Methods 92 cases of rheumatoid arthritis in children were randomly divided into two groups of digital expression , including 46 cases in the control group , for general treatment and non-steroidal anti-inflammatory drugs , anti-rheumatic drugs and glucocorticoids other conventional treatment , six months for a course of treatment , a course of treatment; experimental group of 46 patients, on the basis of conventional therapy plus injection of recombinant human interferon α-1b, 3 ×106 U intramuscular injection three times a week , 6 months for a course of treatment , a course of treatment .46 cases of normal , as normal healthy children.After treatment, compared to patients before and after treatment and CD 69 +CD4+T cells, CD69 +CD8+T cells, CD25 +CD4+T cells, CD25 +CD8+T cells and levels of clinical efficacy .Results The experimental group in serum CD69 +CD4+T cells, CD69 +CD8+ T cells, CD25 +CD4+T cells, CD25 +CD8+T cells in the levels decreased significantly compared with the control group , the difference was statistically significant ( P<0.05);After clinical treatment of children in the experimental group was significantly higher efficiency , the difference was statistically significant (P<0.05).Conclusions The serum rheumatoid joints in CD69, CD25 expression levels were significantly increased;T cells can be activated in arthritic conditions , and to participate in systemic immune response.%目的：探讨α干扰素对类风湿关节炎患儿 CD4＋、CD8＋T 细胞 CD69、CD25表达影响。方法选取我院儿科收治的类风湿关节炎患儿92例，随机分为对照组46例，予一般治疗及非甾体抗炎药、抗风湿药及糖皮质激素等常规治疗，6个月为一个疗程，治疗1个疗程；实验组46例，在常规治疗的基础上加用注射用重组人干扰素α-1b，3×106 U肌注，每周三次，6个月为一个疗程，治疗1个疗程。正常组46例，为正常健康体检儿童。治疗结束后，对比治疗前后患而CD69＋CD4＋T细胞、CD69＋CD8＋T细胞、CD25＋CD4＋T细胞、CD25＋CD8＋T细胞含量水平及临床疗效。结果①治疗后两组患儿血清中CD69＋CD4＋T细胞、CD69＋CD8＋T细胞、CD25＋CD4＋T细胞、CD25＋CD8＋T细胞含量水平改善，且实验（1）组患儿血清中CD69＋CD4＋T细胞、CD69＋CD8＋T细胞、CD25＋CD4＋T细胞、CD25＋CD8＋T细胞含量水平较对照组明显下降，差异有统计学意义（P＜0．05）；（2）治疗后实验组患儿临床治疗有效率明显高于对照组，差异有统计学意义（P＜0．05）。结论类风湿关节患儿血清中CD69、CD25表达水平明显增高，T细胞在关节炎病症中能够被激活，并参与全身免疫应答。