Objective To explore the value of detection of PCT , CRP and platelet count in assessing the severity and prognosis of sepsis .Methods A total of 72 cases with sepsis during January 2010 and December 2014 were retrospectively analyzed .They were divided into two groups according to prognosis , 54 patients with good prognosis were in the NO one group , another 18 patients with poor prognosis were in the NO two group .The concentrations of PCT , CRP and platelet count between two groups were compared . The sensitivities , specificities , the severity and prognosis of the three indexes in diagnosing sepsis were studied .Results PCT of the two groups were greater than 0.05,or PCT could be characterized by 0.05-2 or 2-10 or higher than10.The concentrations of CRP in both groups were greatly increased , platelet count had no apparently unusual in patients with good prognosis , and 89%of the patients with thrombocytopenia were with poor prognosis .Conclusions In the diagnostic sensitivity of sepsis , PCT and CRP were obviously superior to platelet count , but PCT and CRP wouldn't reflect the prognosis of sepsis truly .The platelet count offered little sensitivity , but once appeared obvious drop it suggests a critical condition , the prognosis will be poor , it could put forward warnings to patient prognosis.%目的：探讨降钙素原（ PCT）、血小板计数、C反应蛋白（ CRP）检测在判断脓毒血症病情严重程度及转归的价值。方法选取2010年1月至2014年12月在我院重症医学科确诊为脓毒血症病例进行分析，共72例。根据其严重程度及预后，分为第一组：病情好转组（病情治愈或病情好转，转出ICU至普通病房），共54例；第二组：预后不佳组（死亡及病情明显恶化）共18例，比较两组PCT、血小板计数、C反应蛋白变化，比较三者在脓毒血症诊断的敏感性、特异性、反映病情的严重程度以及预后的关系。结果两组病人PCT均大于0．05，两组病人PCT均可表现为0．05－2或2－10、≥10，两组病人C反应蛋白均明显升高，血小板在病情好转组均无明显异常，而血小板明显低下者，89％患者预后不佳（死亡及病情明显恶化）。结论在脓毒血症的诊断上， PCT及C反应蛋白敏感性明显优于血小板计数，但PCT及CRP数值不能很好反映预后，血小板计数虽敏感性差，但一旦出现明显下降，提示病情危重，预后不佳，可对病人预后提出警示。
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