Objective:To investigate the expression and alteration of protein-A(PAPP-A) and hypersensitive C-reactive protein (hsCRP) in serum of preeclampsia and to discuss their roles in the pathogenesis of pre-eclampsia. Methods:The expression of PAPP-A and hsCRP in serum of 60 women with PE were tested,who were divided into mild group (n=3Q) and serious group(n=30) ,and 30 healthy pregnant women were chosen as control. Furthermore, clinical and biochemical parameters were analyzed for their correlations. Results :①The mean fetus birth weight,Apgar score,placenta weight were markedly lower in SPE group than those in control group (P<0.05) ,also the incidences of small gestational age fetus and neonatal asphexia were higher in SPE group than those in control group(P<0.05).②The levels of serum PAPP-A in control group,mild and severe PE groups increased gradually,there were significant differences among the groups (P<0.05). ③The serum PAPP-A were positively correlated with the serum hsCRP expressions in three groups (P<0.05). While there were no correlation between the level of serum hsCRP and HCT in the three groups(P>0.05). The serum levels of hsCRP and PAPP-A in mild and severe PE group were positively correlated with the diastolic pressure ( DP) and the 24 hours urine protein ( P < 0. 05). Conclusions: The increase of PAPP-A and hsCRP in serum may be an important elements involved in the pathogenesis of preeclampsia, and especially for their coactions.%目的:探讨妊娠相关蛋白-A( PAPP-A)及超敏C反应蛋白(hsCRP)在子痫前期发病中的作用.方法:选择年龄、孕产次相匹配的轻度子病前期(MPE组)、重度子病前期(SPE组)及正常妊娠孕妇(对照组)各30例.检测其血清PAPP-A和hsCRP水平,分析二者与相关临床资料的相关性.结果:①SPE组的新生儿出生时平均体重、Apgar评分、胎盘重量均显著低于对照组,差异有统计学意义(P＜0.05),小于胎龄儿发生率、新生儿窒息率明显高于对照组,差异有统计学意义(P＜0.05).②对照组、MPE组及SPE组血清PAPP-A和hsCRP水平依次增高,两两比较,差异均有统计学意义(P＜0.05).③3组血清PAPP-A与hsCRP水平均呈明显正相关(P＜0.05)；3组孕妇血清hsCRP水平与HCT均无明显相关性(P ＞0.05)；MPE及SPE组血清PAPP-A和hsCRP水平与舒张压及24小时尿蛋白定量均呈明显正相关(P＜0.05).结论:PAPP-A及hsCRP水平升高可能是子病前期发病的重要因素,二者可能共同参与子痛前期发病.
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