目的：利用患者的CT数据，应用Mimics软件精细化对骨缺损区建模，确定3D打印技术在精细化构建组织工程骨方面的可行性，摸索应用Mimics软件构建组织工程支架材料的技术要点。方法：采集患者颌骨缺损区CT数据，利用阈值分割与区域增长相结合的方法分割图像，通过布尔运算获得目标蒙罩后进行三维重建，结合计算机辅助设计来构建个性化、具有内部结构的骨组织工程支架三维数字模型，并以聚乳酸为原材料借助3D打印技术制备支架材料。结果：利用Mimics软件成功地构建出了骨缺损区的数字化三维模型。构建的支架材料模型与患者骨缺损区形态匹配、具有一定内部形态和结构，模型可通过STL （stereo lithography，光固化立体造型术）标准格式导出，格式通用。结论：基于CT扫描数据，利用Mimics软件及计算机辅助设计，可以高效、便捷地构建骨缺损区支架材料的数字化三维模型。%Objective To study 3D construction and printing of bone tissue engineering scaffolds by bone defect modeling on Mimics software based on CT data. Methods CT data of jaw bone defect from patients were acquired and the images were segmented using threshold segmentation combined with region growing . The three dimensional model was reconstructed by Boolean operation. The individual 3D digital model was reconstructed with internal structure by combining with computer; preparing poly-lactic acid scaffold in virtue of 3D technology. Results Using the Mimics software, we successfully constructed a 3D digital reconstruction model of bone defect based on CT data. The constructed scaffold model with certain internal form and structure was matched with the bone defect of patients, and the constructed model was exported onto STL standard format, which may be in common use. Conclusion The 3D digital model of bone defect scaffolds may effectively be reconstructed based on the CT data using Mimics software and computer aided design.
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