目的:了解婴儿胆汁淤积性黄疸的病因、临床特点及转归情况。方法:回顾性分析175例胆汁淤积患儿的临床资料,电话随访转归情况。结果:175例胆汁淤积患儿病因分析示胆道闭锁为42例,死亡19例,肝移植恢复良好4例,肝硬化等待肝移植8例,葛西手术后恢复良好 5例,失访6例;胆管发育不良2例均恢复良好;先天性胆管扩张2例均恢复良好。CMV感染29例均恢复良好。遗传代谢性疾病16例,其中Citrin 蛋白缺陷病13例,恢复良好10例,失访2例,死亡1例;酪氨酸血症3例,恢复良好1例,失访 1例,肝硬化等待肝移植1例。TPN相关性胆汁淤积4例均恢复良好。病因未明80例,恢复良好79例,失访1例。临床特点提示胆汁淤积性黄疸患儿常伴有粪便颜色改变、肝脾肿大等,常合并肺炎、低蛋白血症、凝血功能障碍等。结论:胆汁淤积性黄疸患儿病因较多,早期诊治,预后更好。%Objective To learn about the etiology , clinical characteristics and prognosis of infants with cholestasis jaundice. Methods The clinical data of 175 cholestatic patients were retrospectively analyzed , then the prognosis was followed-up with telephone. Results After analyzing the etiology , we found that among 175 patients , there were 42 with biliary atresia , of which 19 infants died , 4 recovered well after liver transplanta-tion , 8 had liver cirrhosis waiting for transplantation , 5 recovered well after Kasai Portoenterostomy and 6 lost contact. There were 2 patients with Bile duct dysplasia and 2 with congenital cholangiectasis and they had posi-tive outcomes. And 29 patients with Cytomegalovirus infection also had positive outcome. There were 16 patients with Heredity metabolic diseases , among which 13 patients were with Citrin protein deficiency; 10 had positive outcomes; 2 lost contact and 1 died. There were 3 patients with tyrosinemia , of which one had positive outcome;one lost contact and another got liver cirohosis waiting for liver transplantation. Four patients with TPN-related cholestasis all had positive outcomes. There were still 80 cases with unkown etiology , but 79 had positive out-comes and 1 case lost. The clinical characteristics showed that the infants with cholestatic jaundice often accom-panied by stool color changed , liver and spleen enlargement and so on , and often complicated with pneumonia , hypoalbuminemia and coagulation dysfunction and so on. Conclusion There are many etiologies for infants with cholestatic jaundice. Early diagnosis and early treatment would benefit the prognosis.
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