非酒精性脂肪性肝病对急性胰腺炎严重程度的影响

摘要

目的 通过对急性胰腺炎患者的资料进行回顾性分析,评估非酒精性脂肪性肝病与急性胰腺炎严重程度之间的关系,为急性胰腺炎的诊疗、严重程度评估、预后判断、防治提供临床依据.方法应用SPSS 22.0对所有数据进行整理分析.两样本间的计量资料比较应用Mann-Whitney U检验(非正态分布),计数资料比较应用χ2检验,危险因素分析采用Logistic回归分析,P<0.05为差异有统计学意义.结果 合并非酒精性脂肪性肝病的患者,其急性胰腺炎的严重程度与不合并非酒精性脂肪性肝病的急性胰腺炎患者比较差异有统计学意义(χ2=3.968,P=0.046).非酒精性脂肪性肝病(95%CI:4.132~22.575, OR=9.658,P<0.01)与急性胰腺炎严重程度间存在相关性.结论 非酒精性脂肪性肝病的严重程度对急性胰腺炎的严重程度有影响;非酒精性脂肪性肝病是影响急性胰腺炎严重程度的危险因素.%Objective To investigate the relationship between nonalcoholic fatty liver disease and the severity of acute pancreatitis,the data of patients with acute pancreatitis was collected to provide clinic basis for the diagnosis and treatment,severity assessment,prognostic judgement,and prevention of acute pancreatitis. Methods SPSS22.0 was used to analyze all data.Mann-Whitney U test(in case of non-normal distribution)was used to compare data between two groups.Chi-square test was used to counting data.Risk factors were analyzed by using logistic regression analysis. Results The severity of acute pancreatitis in patients with nonalcoholic fatty liver disease had a statistically significance with that of patients without nonalcoholic fatty liver disease(χ2=3.968, P = 0.046);nonalcoholic fatty liver disease(95% CI:4.132 ~ 22.575,OR = 9.658,P < 0.01)had a correlation with the severity of acute pancreatitis.Conclusion Nonalcoholic fatty liver disease was associated with the severity of acute pancreatitis.Nonalcoholic fatty liver disease was the risk factors for the severity of acute pancreatitis.