钙结合蛋白S100A9在类风湿关节炎患者血清中的表达及意义

摘要

目的 检测类风湿关节炎(rheumatoid arthritis,RA)患者血清中S100A9水平,探讨其在RA中的作用及与疾病活动度的关系.方法 收集59例不同疾病活动度的RA患者及20例健康志愿者血清.采用酶联免疫吸附实验(ELISA)检测RA患者及健康对照者血清中S100A9水平,分析其与临床及实验室指标相关性.结果 RA患者S100A9水平显著高于健康志愿者(P=0.0419).按DAS28评分分为轻、中和重度活动组RA,重度活动组RA S100A9水平显著高于中度(P=0.0392)、轻度活动组RA患者(P=0.0013).相关性分析显示RA患者S100A9水平与DAS28、RF水平、关节肿胀及压痛数呈正相关(P<0.01).结论 RA患者血清S100A9水平显著增高,与疾病活动度密切相关.血清S100A9水平可以作为评估RA疾病活动度标记物之一.%Objective To investigate the serum level of calcium-binding protein A9(S100A9)in patients with rheumatoid arthritis and explore its potential clinical significance. Methods The serum level of S100A9 was measured by ELISA in 79 rheumatoid arthritis (RA) patients and 20 healthy controls (HC). The correlation of S100A9 level and relevant clinical parameters were analyzed. Results The serum level of S100A9 was significantly increase in RA patients than those in HC. The serum level of S100A9 was higher in high disease activity than that in moderate and low disease activity in the RA group. There was a positive correlation in serum S100A9 level and DAS28 score,Rheumatoid factor,tender joint count and swollen joint count. Conclusion The serum level of S100A9 increases in RA patients and correlates with RA activity.