血视黄醇结合蛋白尿α1微球蛋白尿微量白蛋白检查在糖尿病高血压肾病早期诊断中的临床应用

摘要

Objective To evaluate the clinical value of the levels of serum RBP, urinary α1-MG and m-Alb in early renal injury patients with diabetes or hypertension. Methods Sixty-one cases of patients with diabetes, 55 cases with hypertension and 35 healthy normal controls were selected. The serum RBP, urinary α1-MG and m-Alb were mea-sured. Results The positive rates of RBP, α1-MG and m-Alb in renal injury with diabetes or hypertension were signi-ficantly higher than that of the controls (P<0.01); The positive rates of RBP, α1-MG and m-Alb in simplex diabetes or Hypertension were significantly higher than that of the controls (P<0.05). Conclusion The combined detection of RBP, urinary α1-MG and m-Alb might have important clinical significance in early diagnosis of early renal injury of patients with diabetes or hypertension.%目的：探讨血视黄醇结合蛋白（RBP）、尿α1微球蛋白（α1-MG）和尿微量白蛋白（m-Alb）联合检测对糖尿病和高血压肾病进行早期诊断的临床价值。方法检测61例糖尿病患者、55例原发性高血压患者和35例健康人群血清RBP和尿液α1-MG和m-Alb浓度。结果 RBP、α1-MG和m-Alb浓度在糖尿病肾病和高血压肾病患者中的阳性率明显高于健康对照组（P<0.01）；在单纯糖尿病和单纯高血压患者中的阳性率明显高于健康对照组（P<0.05）。结论 RBP、α1-MG和m-Alb联合检测对糖尿病和高血压肾病进行早期诊断具有重要的临床意义。