Objective: To analyze the clinical and pathological features of rarely encountered primary intraosseous carcinoma (PIOC) of jaw, and to further offer assistance to the necessity for continuing efforts to improve treatment modalities. Method: 12 cases were retrospectively reviewed, which were confirmed to be PIOC treated from February 1995to January 2007. Results: Elderly patients were more common and a mean age of 45.2 years old. All PIOC were found to be located in the mandible. The symptoms were mainly numbness in lower lip and sore jaw. X-ray radiograph usually revealed a cystic, irregular spot-like or worm-eaten shadows, and with large variabilities. All the patients underwent a combined therapy, of which firstly involved DOP induction chemotherapy, 21 days later radical operation was performed,then 2-4 weeks later radiation therapy with curative dose was employed. Conclusion: The main treatment for PIOC is based on radical surgery and further combined with induction chemotherapy and postoperative radiotherapy, which can help to improve treatment gain.%目的:回顾性研究分析临床少见的原发性颌骨内鳞状细胞癌(PIOC)的临床病理表现,为选择合理的治疗方案提供帮助.方法:对1995-02--2007-01间收治的经病理证实的12例PIOC的临床表现、影像学特征、治疗特点等进行综合分析.结果:12例PIOC患者中以中老年多见,平均年龄45.2岁,全发生于下颌骨;临床特点以下唇麻木、下颌肿痛为主:影像学特征为囊状、不规则、点状虫蚀样破坏的阴影,但有较大的变异性.12例均采用综合治疗,即在DOP诱导化疗后21 d施行根治性手术.2～4周后再追加治疗量放射治疗.结论:根治性手术为主结合诱导化疗和术后放疗的综合治疗方法,是PIOC的主要治疗方法,可有助于提高治疗效果.
展开▼
