目的 探讨肠内营养(EN)温度对急性胃黏膜损伤(AGML)大鼠胃肠道并发症的影响.方法 将48只SD大鼠随机分为EN温度10℃组、24℃组、32℃组、40℃组各12只.通过夹闭腹腔动脉30 min造成大鼠胃缺血,松开动脉夹后再灌注形成AGML.每组随机取2只在再灌注1h后处死取胃,其余大鼠再灌注后2h开始给予EN,观察大鼠EN 48 h腹泻、胃潴留、胃肠道积气情况.结果 大鼠胃缺血再灌注1h成功建立了AGML模型.AGML大鼠行早期EN,随着营养液温度的降低,其腹泻发生只数增多,尤以10℃组明显；10℃组与24℃组腹泻开始时间相近；四组胃潴留、胃肠道积气发生率比较,差异无统计学意义(均P＞0.05).结论 AGML大鼠腹泻与EN温度有关,应提高EN温度至少达24℃,以40℃最佳.%Objective To explore the effects of enteral feeding (EF) temperature on gastrointestinal complications in rats induced by acute gastric mucosal lesion (AGML). Methods A total of 48 Sprague-Dawley rats were randomly and commensurately divided into four groups according to EF temperature: 10℃ ,24℃ ,32℃and 40℃. AGML was induced in rats by clamping celiac artery for 30 min and then reperfusing. Two rats from each group were randomly selected to be sacrificed at 1 h after the reperfusion, and their stomachs were harvested. The rest rats were given EF of varied temperatures at 2 h after the surgery. The incidences of diarrhea, gastric retention and flatulence in rats were observed 48 h after the surgery. Results AGML was built from the gastric ischemia-reperfusion 1 h later in rats. The incidence of diarrhea rose as the temperature of EF decreased, the 10℃ group having more cases of diarrhea than the other 3 groups. There were no significant differences in the periods of time to develop post-EF diarrhea between the 10℃ and the 24℃ group. The 4 groups showed no significant differences in the incidences of gastric retention and intestinal flatulence(P>0. 05 for both). Conclusion Diarrhea associates with EF temperature. EF formula should be heated to at least 24℃ , and 40℃ at the best, before it is administered.
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