血清恶性肿瘤特异性生长因子及肝细胞生长因子水平对膀胱癌新生血管相关因子的影响

摘要

Objective:To investigate the effects of tumor specific growth fanctor (TSGF)and hepatocyte growth factor(HGF) in serum on neovascularization factors in bladder cancer patients.Methods:91 cases of bladder cancer patients including grade Ⅰ 24 cases,30 cases of patients with grade Ⅱ,Ⅲ grade 26 cases,Ⅳ grade 1 1 patients were enrolled.TSGF and HGF,the vascular endothe-lium growth factor (VEGF),the basic fibroblast growth factor (b-FGF)and the angiopoietins-1 (Ang-1 )were detected.Results:TSGF and HGF in patients with grade Ⅱ compared with grade Ⅰ showed significantly higher level (P <0.05),TSGF and HGF of Ⅲ grade patients compared with gradeⅠ,Ⅱ grade were significantly higher (P <0.05),TSGF and HGF of Ⅳ grade compared with grade Ⅰ,Ⅱ,Ⅲ were significantly higher (P <0.05 ).VEGF in grade Ⅱ patients was significantly higher than that in grade Ⅰ (P <0.05 ), VEGF in stage Ⅲ patients compared with Ⅰ,Ⅱ significantly increased (P <0.05),b-FGF and Ang-1 compared with Ⅰ stage patients significantly increased (P <0.05),VEGF in stage Ⅳ compared with grade Ⅰ,Ⅱ,Ⅲ showed significant difference (P <0.05),b-FGF and Ang-1 compared with grade Ⅰ,Ⅱ grade showed significant difference (P <0.05 ).TSGF with VEGF,b-FGF and Ang-1 showed significant positive correlation (P <0.05),HGF and VEGF showed significant positive correlation (P <0.05 ).Conclusion:Elevated levels of HGF and TSGF is an important factor leading to bladder cancer progress,the process may be related to the elevated levels of neovasculization correlation factor.%目的：研究血清恶性肿瘤特异性生长因子（TSGF）及肝细胞生长因子（HGF）水平对膀胱癌新生血管生成的影响。方法：选择到本院泌尿外科就诊的91例膀胱癌患者，Ⅰ期24例，Ⅱ期30例，Ⅲ期26例，Ⅳ期 1 1例，对各期患者血清 TS-GF 及 HGF、血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（b-FGF）及促血管生成素1（Ang-1）进行检测。结果：Ⅱ期患者 TSGF 及 HGF 较Ⅰ期出现显著升高（P ＜0．05），Ⅲ期患者 TSGF 及 HGF 较Ⅰ期、Ⅱ期均出现显著升高（P ＜0．05），Ⅳ期患者 TSGF 及 HGF 较Ⅰ期、Ⅱ期、Ⅲ期均出现显著升高（P ＜0．05）；Ⅱ期患者 VEGF 较Ⅰ期显著升高（P ＜0．05），Ⅲ期患者VEGF 较Ⅰ期、Ⅱ期均出现显著升高（P ＜0．05），b-FGF 及 Ang-1较Ⅰ期患者均出现显著升高（P ＜0．05），Ⅳ期患者 VEGF 较Ⅰ期、Ⅱ期、Ⅲ期出现显著差异（P ＜0．05），b-FGF 及 Ang-1较Ⅰ期、Ⅱ期出现显著差异（P ＜0．05）。TSGF 与 VEGF、b-FGF 及Ang-1呈显著正相关（P ＜0．05），HGF 与 VEGF 呈显著正相关（P ＜0．05）。结论：TSGF 及 HGF 水平升高可能是导致膀胱癌进展的重要因素，该过程与新生血管生成相关因子水平升高可能相关。