FRAX对老年骨质疏松性脊柱骨折的预测诊断价值分析

摘要

Objective:To analyze the value of fracture risk assessment tool(FRAX) in predictive diagnosis of spinal fracture for elderly patients with osteoporosis.Methods:Clinical data of 96 patients with osteoporosis received treatment in our hospital were analyzed.Patients were divided into observation group(fracture,n=45) and control group(not fracture,n=51) by whether suffered from spinal fracture.All patients were treated with FRAX and osteoporosis self-assessment tool for asians (OSTA),and received the test of bone density measurement.Results:Patients in the observation group had higher FRAX score,but lower OSTA score and bone density value than these in the patients of the control group,the differences were statistically significant (P<0.05).ROC analysis showed that the FRAX score index (cut-off point value of 3.92) was used for predictive diagnosis of spinal fracture for elderly patients with osteoporosis,and provided a sensitivity of 92.16%,a specificity of 84.44%,area under the curve of 0.94,were better than these of OSTA.Correlation analysis showed that the levels of bone density value in the patients of the observation group had significant negative correlation with FRAX score (r=-0.538,P<0.01),which was statistically significant.Conclusion:In predictive diagnosis of spinal fracture for elderly patients with osteoporosis,the FRAX is valuable,be worthy of clinical expansion.%目的:分析骨质疏松性骨折风险预测简易工具(fracture risk assessment tool,FRAX)对老年骨质疏松性脊柱骨折发生的预测诊断价值.方法:分析在本院接受诊疗的96例老年骨质疏松患者的临床资料,依据是否合并骨质疏松性脊柱骨折将患者分为观察组(骨折,n=45)及对照组(未骨折,n=51).每位患者均行FRAX及骨质疏松自我筛查工具(osteoporosis self-assessment tool for asians,OSTA)评估,并接受骨密度测量.结果:观察组患者FRAX指数显著高于对照组患者,而OSTA指数及骨密度值均显著低于对照组患者,各项差异均具有统计学意义(P<0.05).ROC曲线分析显示,以3.92为截点值,FRAX 指数预测诊断老年骨质疏松性脊柱骨折的敏感性为92.16%,特异性为84.44%,曲线下面积为0.94,优于OSTA指数.相关性分析显示观察组患者FRAX指数与骨密度值呈现显著负相关,具有统计学意义(r=-0.538,P<0.01).结论:FRAX在预测老年骨质疏松患者脊柱骨折发生中具有一定价值,该工具具有临床推广价值.