Objective:To research the effects of probucol on patients’ serum hs-CRP,IL-1,andIL-6 with early-stage diabetic nephropathy. Methods:104patients with early-stage DN were randomly divided into two groups,on the basis of conventional treatment,one group is blank control group and the other is experimental group, blank control group only received conventional treatment,experimental group received conventional treatment and Probucol (500mg/once,BID),After 8 weeks, to compare the hs-CRP、IL-1、IL-6,fasting blood glucose,blood pressure,UAER,LDL-C,HDL-C,TC,TG in the two group before and after the treatment. Result There were no significant differences in the levels of hs-CRP、IL-1、IL-6,fasting blood glucose,blood pressure, UAER,LDL-C,HDL-C,TC,TG between the two group before the treatment (P>0.05),After 8 weeks,with different treatments,in the blank control group,there were no significant changer in the levels of hs-CRP、IL-1、IL-6,fasting blood glucose,blood pressure, UAER,LDL-C,HDL-C,TC,TG(P>0.05),but in the experimental group,the levels of hs-CRP、IL-1、IL-6,UAER,LDL-C,HDL-C, TC,TG declined sharply (P<0.05).Conclusion:There were no significant differences in the levels of the fasting blood glucose and blood pressure between the blank control group and the experimental group,But Probucol can not only decrease the level of blood-lipid,but also decrease the serum hs-CRP,IL-1,andIL-6 in the patients with early-stage DN,in this way,it could protect the kidney from damaging.% 目的：探讨普罗布考影响早期糖尿病肾病患者血清hs-CRP和炎性细胞因子IL-1、IL-6水平。方法：将104例早期糖尿病肾病患者随机分为实验组与对照组，实验组除了常规治疗外还加用了普罗布考（500mg/次，BID），治疗8周，对照组仅给予常规治疗，比较两组不同的处理前后的hs-CRP、IL-1、IL-6、空腹血糖、血压、24小时尿微量白蛋白排泄率、低密度脂蛋白、高密度脂蛋白、血清总胆固醇、甘油三脂的高低。结果：治疗前两组的hs-CRP、IL-1、IL-6、空腹血糖、血压、24小时尿微量白蛋白排泄率、低密度脂蛋白、高密度脂蛋白、血清总胆固醇、甘油三脂比较，差异无统计学意义（P＞0.05），经过不同处理，8周后，实验组血清hs-CRP、IL-1、IL-6和24小时尿微量白蛋白排泄率明显降低，与对照组比较差异有统计学意义（P＜0.05）；实验组血清低密度脂蛋白、高密度脂蛋白、血清总胆固醇和甘油三脂水平改善程度明显优于对照组，差异有统计学意义（P＜0.05）。但两组空腹血糖和血压差异无统计学意义（P＞0.05）。结论：普罗布考治疗早期糖尿病肾病的疗效显著，不仅能降低血脂，还起到降低早期糖尿病肾病患者血清中的hs-CRP、IL-1、IL-6水平，从而达到保护肾功能免受损害的作用。
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