幽门螺杆菌根除疗效与CYP2C19基因多态性的相关性研究

摘要

Objective:To study and analyze the correlation between Helicobacter pylorieradication efficacy and CYP2C19 gene polymorphism. Methods:Collection of patients with chronic gastric ulcer 100 cases, were randomly divided into observation group and control group, each of 50 cases, two patients were using clarithromycin and amoxicillin treatment, patients in the control group using esomeprazole treatment,patients in the observation group use of lansoprazole treatment, the CYP2C19genotypes of two groups were determination and comparison, at the end of treatmentfor Helicobacter pylori eradication effect detection. Results:The patients in the observation group and the control group of patients with Helicobacter pylorieradication rate of P>0.05 said the difference was not statistically significant; theCYP2C19 genotypes of Helicobacter pylori in control group of weak metabolic type,intermediate metabolism and metabolic type fast eradication rate did not show significant difference (P>0.05);and observe the eradication of type of weakmetabolism the group was significantly higher than that of fast metabolism(P<0.05).Conclusion:The CYP2C19 gene in Helicobacter pylori eradication treatment processof a patient,can provide effective drug selection reference value.%目的：研究和分析幽门螺杆菌根除疗效与CYP2C19基因多态性的相关性。方法：收集慢性胃溃疡患者100例，随机分为观察组与对照组，各50例，两组患者均使用克拉霉素和阿莫西林进行治疗后，对照组患者使用埃索美拉唑进行治疗，观察组患者使用兰索拉唑进行治疗，将两组患者的CYP2C19基因型进行测定和对比，在治疗结束后对幽门螺杆菌的根除效果进行检测。结果：观察组患者和对照组患者的幽门螺杆菌根除率，以P＞0.05表示差异无统计学意义；通过CYP2C19基因分型，对照组患者中弱代谢型、中间代谢型和快代谢型的幽门螺杆菌根除率无显著差异（P＞0.05）；而观察组弱代谢型的根除率明显高于快代谢型（P<0.05）。结论：在幽门螺杆菌的根除治疗过程中，通过CYP2C19基因多态性的检测，能够提供有效的用药选择参考价值。