目的:探讨白三烯在肺炎支原体(MP)感染发病机制中的作用.方法:收集住院确诊为MP感染的60例患儿为MP感染组,其中轻度感染10例,中度感染31例,重度感染19例.另选择同期门诊正常健康体检的60名儿童为正常对照组.用双抗体夹心ELISA法检测两组儿童血清白三烯B4(LTB4)和尿白三烯E4(LTE4)水平.结果:MP感染组血清LTB4及尿LTE4的水平均明显高于正常对照组(P均<0.01).MP感染患儿血清LTB4的水平和尿LTE4的水平呈正相关 (r=0.522,P<0.01),且均与MP感染的病情呈正相关(rs分别为0.617、0.567,P均<0.01).结论:MP感染患儿的血清LTB4、尿LTE4水平均明显升高,并且血清LTB4、尿LTE4与MP感染病情有关,白三烯在MP感染的发病机制中可能起重要作用.%Objective: To investigate the roles of leukotrienes in the children with MP infection. Methods: Sixty children with MP infection in clinic were enrolled into MP infection group , and assigned into, they were divided into mild infection group (n =10) , median infection group (n =31) and severe infection group (n =19) , according the severity. Sixty healthy children in routing physical examinations in outpatient department were select -ed as normal controls. Serum leukotriene B4 (LTB4) and urine leukotriene (LTE4) were assessed by ELISA. rnResults: Significantly higher serum LTB4 and urine LTE4 were revealed in the MP infection group than those inrn normal control group (P <0. 01). There was significantly positive correlation revealed between the serum LTB 4 and the urinary LTE4 in the MP infection group ( r = 0. 522, P < 0. 01). There were also significantly positive cor ?relation between the serum LTB 4 or urinary LTE4 and the severity of MP infection ( rs = 0. 617 and 0. 567, P <0. 01). Conclusion: LTB4 and LTE4 are elevated in the MP infection and positively correlated with the severi -ty of MP infection, suggesting that they play important roles in MP infection.
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