阴道摄入戊酸雌二醇在薄型子宫内膜不育症中的临床疗效分析

摘要

目的：观察并评价阴道摄入戊酸雌二醇对女性薄型子宫内膜不育症的临床治疗疗效。方法观察256例子宫内膜过薄导致不育症的患者，经患者知情同意，按照数字表法随机分为观察组和对照组各128例。对照组采用口服戊酸雌二醇治疗，观察组采用阴道摄入戊酸雌二醇治疗，观察治疗前后2组患者排卵日子宫内膜厚度变化和血液流变学改善情况，并随访2组患者1年内的妊娠及流产情况。结果观察组较对照组治疗后排卵日子宫内膜厚度明显增加，差异有统计学意义（ P＜0．01）；观察组较对照组治疗后排卵日子宫内膜血流情况出现明显改善，差异有统计学意义（P＜0．05）；观察组治疗后1年妊娠率显著高于对照组，同时流产率也显著低于对照组，差异均有统计学意义（ P＜0．01或P＜0．05）。结论采用阴道摄入戊酸雌二醇治疗女性薄型子宫内膜不育症，能显著改善子宫内膜厚度及血流情况，明显提高患者的临床受孕率，其疗效显著优于口服戊酸雌二醇。%Objective To investigate and evaluate the therapeutic effects of estradiol valerate through vaginal drug delivery in the treatment of female infertility due to thin endometrium .Methods Close observation was made on the 256 female infertility patients due to thin endometrium.With the knowledge and consent of the patients , the patients were divided into 2 groups, the observation group and the control group .The control group received oral estradiol valerate , while the observation group was treated with estradiol valerate through vaginal drug delivery .Changes in the thickness and blood flow improvement of endometrium in ovulation days were closely ob -served in the patients of the 2 group.Then, one-year follow-up was made on the pregnancy rate and abortion rate in the patients of the 2 groups.Results The endometrial thickness in the observation group was significantly increased , as compared with that of the control group, with statistical significance (P<0.001).Following treatment, endometrial blood flow in the observation group was obviously improved, when compared with that of the control group , also with statistical significance (P<0.05).One year after treatment, the pregnancy rate of the observation group was significantly higher than that of the control group , and statistical significance could be seen when comparisons were made between the 2 groups (P<0.01).At the same time, the abortion rate of the observation group was obvi-ously lower than that of the control group (P<0.05).Conclusion Estradiol valerate through vaginal delivery in the treatment of female infertility due to thin endometrium could significantly improve the endometrial thickness and blood flow in ovulation days and increase pregnancy rate .The therapeutic effects of vaginal drug delivery were significantly superior to oral administration of estradiol valerate .