膝骨关节疼痛患者血液尿酸水平研究

摘要

Objective To explore the level of blood uric acid in patients with knee osteoarthritis pain, so as to provide acces-sory diagnosis of osteoarthritis ( OA) .Methods From Oct of 2010 to Dec of 2015, 1174 patients who complained of osteoarthritis pain were recruited through the Outpatient Department.Fasting blood samples were collected for the detection of uric acid level, and VAS scores were used to assess the severity of osteoarthritis pain.Results One thousand one hundred and seventy-four subjects (250 males and 924 females) were divided into 2 groups.The blood uric acid level for the females was(277.08 ±67.07)μmol/L, while the uric acid level for the males was(347.31 ±88.48)μmol/L, and statistical significance could be seen, when comparisons were made be-tween them( P<0.01) .The level of uric acid P25 of the females was 232μmol/L, while that of the males was 295μmol/L.The uric acid of the females increased with the increase of age, while that of the males below the age of 70 decreased with the increase of age.In the females, the VAS scores increased with the increase of uric acid level, and the higher the VAS scores, the higher the uric acid lev-el, and statistical significance could be noted, when comparisons were made between them (P<0.001).Results indicated that there was association between VAS scores and uric acid level for the males.Conclusion When the uric acid level for the male was above 295μmol/L and that for the female was above 232 μmol/L, it was of clinical significance for the diagnosis of osteoarthritis.The uric acid level of the females increased with the increase of age and the elevation of VAS scores, indicating that efforts should be made on the part of females to control their food intake.%目的：探讨主诉为膝骨关节疼痛患者血液尿酸分布情况，为骨关节炎（ osteoarthritis，OA）提供辅助诊断。方法2012年12月至2015年12月通过门诊收集主诉为骨关节炎疼痛的患者1174名，空腹血检测血液尿酸水平，VAS评分评估骨关节炎疼痛程度。结果 1174例研究对象男女分别为250和924人，其中女性尿酸水平为（277．08±67．07）μmol／L，男性尿酸水平为（347．31±88．48）μmol／L，差异有统计学意义（P＜0．01），女性尿酸P25为232μmol／L，男性尿酸P25为295μmol／L。女性尿酸水平随年龄增长而上升，男性在70岁以下尿酸随年龄增长而有下降趋势。女性VAS评分越高，尿酸水平越高，差异有统计学意义（P＜0．01）；男性未观察到VAS评分与尿酸之间的相关性。结论骨关节炎患者存在尿酸水平升高，男女性水平分别超过295μmol／L和232μmol／L时对临床诊断有帮助。女性尿酸随年龄增长、VAS评分增加而上升，提示女性加强饮食控制。