晚期非小细胞肺癌恶病质患者血清IL-1和GH/IGF-1水平的变化及意义

摘要

目的：观察晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)恶病质患者血清白细胞介素-1(interleukin-1, IL-1)、生长激素(growth hormone, GH)/胰岛素样生长因子-1(insulin-like growth factor 1, IGF-1)水平的变化及其意义。方法：选取41例晚期NSCLC恶病质患者为恶病质组；42例晚期NSCLC非恶病质患者为非恶病质组；另选取24例健康就诊者为对照组。检测所有入选者的营养参数包括体质量指数(body mass index, BMI)、上臂中部臂围(mid-upper arm circumference, MAC)及血清白蛋白(albumin, ALB)；并用酶联免疫吸附法检测入选者血清IL-1、GH和IGF-1的含量。结果：(1)与对照组相比，非恶病质组BMI、MAC及ALB的差异无统计学意义(P＞0.05)，恶病质组BMI、MAC及ALB均明显降低(P＜0.05)；与非恶病质组相比，恶病质组BMI、MAC及ALB均明显降低(P＜0.05)。(2)与对照组相比，非恶病质组及恶病质组血清IL-1、GH及IGH表达均明显增加(P＜0.05)，恶病质组GH/IGF-1升高(P<0.05)；与非恶病质组相比，恶病质组血清IL-1及GH表达增加(P＜0.05)，而IGF-1表达降低(P＜0.05)，GH/IGF-1升高(P<0.05)。结论：晚期NSCLC恶病质患者营养状况明显恶化，IL-1和GH/IGF-1的变化可能介导了晚期NSCLC患者恶病质的发生。%Objective:To study the expression of serum interleukin-1(IL-1) and growth hormone/insulin-like growth factor 1 (GH/IGF-1) levels in advanced non-small cell lung cancer(NSCLC) patients with cachexia and its significance. Methods: 41 cases of NSCLC patients with cachexia were used as the cachexia group; 42 cases of NSCLC patients without cachexia were used as the non-cachexia group; and 24 healthy people were taken as normal controls. All the subjects were tested the nutrition index such as:body mass index(BMI), mid-upper arm circumference(MAC) and serum albumin(ALB);and the serum levels of IL-1, GH and IGF-1 were detected by enzyme-linked immunoabsorbent assay(ELISA). Results: (1)Compared with control group and non-cachexia group, the nutrition index: BMI, MAC and ALB were significantly decreased in the cathexia group(P<0.05). (2)Compared with control group, the expression of IL-1, GH and IGF-1 in non-cachexia group and cathexia group were all increased(P<0.05),GH/IGF-1 in cathexia group was increased(P<0.05). Compared with non-cachexia group, the expression of IL-1, GH in cachexia group were increased(P<0.05), while the expression of IGF-1 was decreased(P<0.05), GH/IGF-1 was increased(P<0.05). Conclusion: Nutrition status decreases in NSCLC patients with cachexia. The changes of serum IL-1 and GH/IGF-1 levels may play a role in the occurrence of cachexia in NSCLC patients.