熊果酸对大鼠体内瑞舒伐他汀的药代动力学影响

摘要

目的：探讨熊果酸对大鼠体内瑞舒伐他汀的药代动力学影响。方法12只雄性 SD 大鼠（200～235 g）按随机数字表法分为2组，分别为单用瑞舒伐他汀组与瑞舒伐他汀合用熊果酸组，每组6只，以瑞舒伐他汀100 mg· kg-1、熊果酸80 mg·kg-1的剂量灌胃给药，两药合用时先熊果酸后瑞舒伐他汀相继灌胃。采用 LC-MS 测定血药浓度，比较2组间药代动力学参数。结果合用熊果酸后，瑞舒伐他汀药代动力学参数 Cmax、AUC0-t、AUC0-∞参数值分别增加163．02％、145．99％和157．55％，而 CLz/F 值降低了57．84％（P ＜0．05或 P ＜0．01）。结论熊果酸可影响大鼠体内瑞舒伐他汀的药代动力学特性。%Objective To study the effect of ursolic acid on the pharmacokinetics of rosuvasta-tin in rats.Methods Twelve male rats(200-235 g)were randomly given rosuvastatin alone(con-trol group)or in combination with ursolic acid(treatment group),with 6 rats in each group.Rosu-vastatin(100 mg·kg-1 ),ursolic acid(80 mg·kg-1 )were adiministered by intragastric adminis-tration.Combination of both recipes were adiministered first ursolic acid.LC-MS was used to de-termine the plasma concentrations of rosuvastatin.Pharmacokinetic parameters were compared between the two groups.Results Compared with control group,Cmax ,AUC0-t and AUC0-∞ parame-ters were respectively increased by 163.02%,145.99% and 157.55%,but CLz/F was decreased by 57.84% in treatment group(P <0.05 or P <0.01).Conclusion Ursolic acid can affect the pharmacokinetic properties of rosuvastatin in rats.