奥沙利铂联合5-FU/CF方案治疗晚期结肠癌的临床观察

摘要

目的:评价奥沙利铂(L-OHP)联合5-FU/CF方案治疗晚期结肠癌的临床疗效和不良反应.方法:43例晚期结肠癌患者,给予L-OHP 130mg/m2静脉滴注,持续4h,d1;CF 150mg/m2静脉滴注,持续2h,d1-d5;5-FU 500mg/m2静脉滴注,持续6h,d1-d5.每3周重复1次.结果:43例患者中,完全缓解(CR) 1例,部分缓解( PR) 11例,稳定( SD) 17例,进展( PD)11例,总有效率(CR + PR)34.9%.不良反应主要是末梢神经毒性、恶心呕吐、腹泻、骨髓抑制等,均可耐受.结论:L-OHP联合5-FU/CF方案治疗晚期结肠癌疗效好,不良反应主要是末梢神经毒性和胃肠道反应.%Objective:To evaluate the therapeutic effect and toxicity of oxaliplatin plus 5-FU/CF in the treatment of advanced colorectal cancer.Methods:Forty three patients with advanced colorectal cancer received L-OHP plus 5-FU /CF.L-OHP 130mg/m2 was administered,iv infusion 4h,d1;leucovorin (CF) 150mg/m2,iv infusion for 2h,d1-5;followed by 5-FU 500mg/m2 ,iv infusion over a period of 6h,d1-5.This regimen was repeated every 3 weeks.Results:Among 43 patients,there were 1 CR,14 PR,17 SD and 11 PD,the overall response rate (CR + PR) was 34.9%.The major toxicities were nausea and vomiting,neurosensory toxicity and neutropenia,but they were tolerable.Conclusion:The combination of oxaliplatin and 5-FU /CF is an effective and tolerable regimen for treatment of advanced colorectal cancer.