目的:总结高频超声在Mammotome旋切系统微创治疗乳腺良性肿块中的临床价值及应用经验.方法:对50例个经临床与超声诊断为乳腺良性肿块的女性患者,在高频超声引导下行Mammotome微创旋切治疗,对超声引导情况及旋切治疗效果进行评价.结果:高频超声清晰地显示了取样全过程,显示率100%.50例共83个乳腺肿块均完全切除.结论:高频超声在Mammotome旋切系统微创治疗乳腺良性肿块中具有操作简单、定位准确、无创伤等优点,能术前定位、术中引导监测、术后疗效评估,具有重要的临床价值.%Objective :To investigate the expression and significance of HIF - 1α, NOS2 , VEGF in human GIST. Methods : Total of 124 GIST specimens and their normal counterparts were detected for protein expression of HIF 1α,NOS2,VEGF. Results: The positive expression of HIF - 1αin 124 cases of GIST was found in 79 cases ( 63. 7％ ), positive expression of NOS2 was found 80 cases ( 64. 5％ ), positive expression of VEGF was found in 72 cases ( 58. 1％ ). The expression was closely related to NIH classification, mucosal invasion and metastasis. The positive correlation was found between the 3 genes. Conclusion : The expression of HIF - 1α , NOS2 ,VEGF is up - regulated in GIST and they may play an important role in the genesis and development of GIST and find effective the rapeutic method. It is feasible to use tissue micro - array for a rapid screen of massive tissue specimens clinically and it is an high efficacy, economic and accurate method for detecting clinical specimens.
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