目的:研究我国湖北汉族人群TNF的基因多态性与非霍奇金淋巴瘤(NHL)发病的关系.方法:采用病例对照研究和聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测160例NHL患者和214例健康对照者中TNFα-308、 LTα-252基因型分布.结果:NHL组与健康对照组TNFα-308基因型、等位基因频率总体分布差异无统计学意义(P均>0.05);NHL组与健康对照组相比LTα-252 AA基因型频率相比明显减低,差异有统计学意义(19%比29%,χ2= 4.513,P=0.034,OR=1.697,95%CI:1.039-2.773),而LTα-252 GG 、AG基因型及等位基因频率总体分布差异无统计学意义(P均>0.05);TNFα-308、LTα-252基因型与NHL患者的病理类型、临床分期及进展无明显相关性(P均>0.05).结论:LTα-252位点基因型与湖北汉族人群NHL发病有相关性.%Objective : To study the distrihution of TNF gene polymorphisms in patients with non - Hodgkin's lymphoma ( NHL ) in Hubei province with Han nationality. Methods : Total of 160 patients with NHL and 214 healthy controls were genotyped by the PCR - RFLP method for TNFα - 308 , LTα - 252 polymorphisms. Results : There wasn't significant difference of TNFα - 308 gene polymorphism in NHL group and health control group ( P ＞ 0. 05 ). There was significant difference of LTα - 252 AA genotype between NHL group and healthy control group, the frequency of LTα - 252 AA genotype of NHL patients was significantly lower than that in control group ( P ＜ 0. 05 ). There were no associations between TNFα - 308 . LTα - 252 gene polymorphisms and pathotype, clinical stages and disease progression in NHL patients. Conclusion: LTα - 252 genotype was associated with NHL in Hubei province with Han nationality.
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