Livin与Smac在鼻咽癌组织中的表达及临床意义

摘要

Objective:To investigate the expression of Livin and Smac in nasophaiyngeal carcinoma ( NPC) and their correlation with metastasis and recurrence. Methods: Immunohistochemisty was employed to determine the expression of livin and Smac in 80 NPC tissues and 30 chronic nasopharyngitig tissues. Results: livin was overex-pressed in NPC compared with chronicnasopharyngitis tissues (P =0.000) and Smac was significantly lower compared with chronic nasopharyngitis tissues (P= 0.000). The protein expression of livin was significantly correlated with the cervical lymph node metastasis, distant metastasis, recurrence of tumor and clinic stage(P<0.05) ; The protein expression of Smac was significantly correlated with T stage, cervical lymph node metastasis, distant metastasis, recurrence of tumor and clinic stage (P < 0.05 ). There was a significantly negative relationship of livin with Smac( γ~-0.368,P = 0. 001 ). Conclusion: The inactivation of Smac and overexpression of livin protein might enhance the NPC proliferation and malignance and plays an important role in progress of NPC.%目的:探讨凋亡抑制因子Livin和凋亡促进因子Smac在鼻咽癌组织的表达及相关性,分析其与鼻咽癌转移复发的关系.方法:应用免疫组织化学SP法检测80例鼻咽癌组织和鼻咽慢性炎组织中Livin和Smac 蛋白的表达情况.结果:80例鼻咽癌组织中Livin蛋白表达的阳性率显著高于鼻咽慢性炎组织(P =0.000),癌组织中Smac表达的阳性率显著低于鼻咽慢性炎组织(P=0.000).鼻咽癌组织中Livin的表达与颈淋巴结转移、远处转移、复发及临床分期密切相关(P＜0.05)；Smac的表达与T分期、颈淋巴结转移、远处转移、复发及临床分期密切相关(P＜0.05).Livin和Smac的表达呈显著负相关(y=-0.368,P=0.001).结论:Livin的高表达及Smac的失活可能在鼻咽癌的发生及进展中起着重要作用.