Objective: To investigate the expression of MTA1 in non - small cell lung cancer ( NSCLC ) and the association between it and clinicopathological characters of NSCLC. Methods: MTA1 expression was examined in 96 cases of NSCLC using immunohistochemistry. Results: MTA1 expression in primary NSCLC tissues was higher than that in adjacent normal lung tissues( P <0. 05 ). There was no relationship between MTA1 expression and age, gender, histological type and tumor size( P >0. 05 ). MTA1 expression was significantly correlated with lymph node metastasis and advanced TNM stage ( P <0. 05 ). Conclusion: MTA1 expression in NSCLC was associated with TNM stage and may play important roles in NSCLC development and lymph node metastasis. It may become a potential target of clinical therapy.%目的:研究非小细胞肺癌中MTA1蛋白表达及临床意义.方法:采用免疫组织化学法检测96例非小细胞肺癌组织MTA1蛋白表达情况,并探讨其与非小细胞肺癌临床病理因素的关系.结果:MTA1蛋白在非小细胞肺癌组织中的表达明显高于癌旁正常肺组织(P<0.05),其表达与患者年龄、性别、病理组织学分型及肿瘤大小无明显相关性(P>0.05).MTA1的表达水平与淋巴结转移及TNM分期相关,在有淋巴结转移的病例中的表达(阳性率为75.6%)显著高于无淋巴结转移的病例(阳性率为54.5%),在Ⅲ和Ⅳ期病例中的表达(阳性率为76.3%)显著高于Ⅰ和Ⅱ期(阳性率为55.2%)(P<0.05).结论:MTA1表达水平与患者的TNM分期密切相关,在非小细胞肺癌进展包括淋巴结转移的过程中起到重要作用,可能成为潜在的治疗靶点.
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