目的：探讨甲状腺透明变梁状肿瘤（hyalinizing trabecular tumor，HTT）临床病理特点、诊断及其鉴别诊断。方法：对6例 HTT 组织进行组织形态学观察及免疫组化标记，总结其临床资料和组织病理特征，选用抗体包括 Tg、TTF －1、CK19、Galectin －3、CgA、Ki67等。结果：本组6例患者5女1男，发病平均年龄44岁，肿瘤直径1．5～4．0cm（平均3．0cm）；镜下瘤组织呈梁状，界限清楚，可见薄的纤维膜包绕；瘤细胞呈椭圆形、梭形或多角形，胞浆嗜酸性，细颗粒状，伴有透明变性基质；细胞核可见核沟及假包涵体，核分裂象偶见。免疫组化显示瘤细胞表达 Tg、TTF －1、Galectin －3、Ki67等，其中 Ki67表达定位于细胞膜。结论：甲状腺 HTT 具有较独特的病理组织学改变和免疫表型，诊断依靠形态学特征，免疫组化标记有助于与甲状腺滤泡性腺瘤、甲状腺乳头状癌、甲状腺髓样癌等相鉴别。%Objective:To explore the clinical -pathological characteristics,diagnosis,and differential diagnosis of hyalinizing trabecular tumor(HTT)of the thyroid.Methods:We summarized the clinical data and histopathological features of 6 HTT samples by histomorphological observation and immunohistochemistry analysis.The adopted anti-bodies were Tg,TTF -1,CK19,Galectin -3,CgA,Ki67 etc.Results:Five female and 1 male patients were recriuted in the current study,with an average onset age of 44 years.The diameter of the tumors was 1.5 ~4.0cm (average 3.0cm).The tumor tissues exhibited trabecular pattern,and their boundaries were clear,which were wrapped with fi-brous membranes.The tumor cells were oval,spindle or polygonal,with eosinophilic and granular cytoplasms,and were accompamied with hyaline degeneration of the matrix.Nuclear groove and intranuclear pseudo -inclusions could be checked.The mitotic figures were rarely observed.Immunohistochemistry showed that some markers,such as Tg,TTF-1,Galectin -3,Ki67,were expressed in tumor cells,and the expression of Ki67 was localized in cell membrane. Conclusion:Thyroid HTT exhibits unique pathohistological and immune phenotypes,and the diagnosis relies on mor-phological features.Immunohistochemical staining is helpful in differential diagnosis of thyroid follicular adenoma,pa-pillary thyroid carcinoma,and medullary thyroid cancer,and others.
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