中性粒细胞计数比率与血小板计数比率对胃癌患者预后的临床意义

摘要

目的:探讨中性粒细胞计数比率与血小板计数比率对胃癌患者预后的临床意义.方法:回顾性分析我院2009年3月至2011年3月期间收治的261例胃癌患者,对其临床病理资料进行整理,收集患者术前与术后中性粒细胞计数比率和血小板计数比率与患者的临床病理资料之间的关系.结果:随着肿瘤TNM分期越晚、淋巴结转移个数增加以及肿瘤浸润深度的增加,中性粒细胞淋巴细胞比率(neutrophil lymphocyte ratio,NLR)以及血小板淋巴细胞比率(platelet lymphocyte ratio,PLR)均呈不同程度的增高,差异均具有统计学意义(P＜0.05);肿瘤标志物明显升高的患者其NLR与PLR均异常增高,差异均具有统计学意义(P＜0.05);将临床病理特征以及NLR和PLR进行OS以及DFS的单因素和多因素分析后,结果显示TNM分期、NLR、PLR为胃癌患者预后的独立危险因素.结论:NLR与PLR可以作为胃癌患者预后的独立风险因素.%Objective:To explore the clinical significance of neutrophil lymphocyte ratio and platelet lymphocyte ratio on the prognosis of patients for gastric cancer.Methods:Retrospectively analyse clinical pathological data of 261 gastric cancer patients from our hospital during March 2009 to March 2011,collect and analyze their relationship between neutrophil lymphocyte ratio (NLR),platelet lymphocyte ratio (PLR) and clinical pathologic data of patients.Results:As the increase of TNM stage,lymph node metastasis number and tumor invasive depth,the NLR and PLR were all increased (P ＜ 0.05).The NLR and PLR were all unusually increased,whose tumor markers significantly increased (P ＜ 0.05).The results of analysis between clinical pathological characteristics and NLR,PLR showed that TNM staging,NLR,PLR as independent risk factors for the prognosis of patients with gastric cancer.Conclusion:NLR and PLR can be used as independent risk factors for the prognosis of patients with gastric cancer.