血清miR-17-5p在卵巢癌患者中的表达及临床意义

摘要

Objective:To explore the expression and the clinical significance of serum miR-17-5p in ovarian cancer.Methods:Expressions of serum miR-17-5p were analyzed by qRT-PCR in 77 ovarian cancer patients.Statistical analysis was conducted to analyze the diagnostic and prognostic value of serum miR-17-5p in ovarian cancer.Results:qRT-PCR revealed that the serum miR-17-5p was significantly higher in the serum of ovarian cancer patients than healthy controls.ROC curves revealed that serum miR-17-5p was a promising diagnostic biomarker for ovarian cancer.Chi-square revealed that serum miR-17-5p was statistically significantly associated with clinical stage of ovarian cancer patients.Kaplan-Meier curves revealed that serum miR-17-5p expression was negatively correlated with 5 years survival rate of ovarian cancer patients after surgery,which was statistically significant.Conclusion:miR-17-5p is upregulated in the serum of ovarian cancer patients,and is a promising diagnostic and prognostic biomarker for ovarian cancer.%目的:探讨血清miR-17-5p在卵巢癌患者中的表达及其在诊断及预后方面的价值.方法:利用qRT-PCR方法检测77例卵巢癌患者及健康对照血清标本中miR-17-5p的表达情况,并利用统计学方法分析miR-17-5p的诊断和预后价值.结果:qRT-PCR结果发现血清miR-17-5p在卵巢癌患者中的表达显著高于健康对照组.ROC曲线显示血清miR-17-5p为卵巢癌有效的诊断分子靶点.卡方检验显示血清miR-17-5p与卵巢癌患者的临床分期呈显著正相关.Kaplan-Meier生存曲线显示血清miR-17-5p的表达水平与卵巢癌患者术后5年生存率呈显著负相关.结论:血清miR-17-5p在卵巢癌患者中表达水平显著增高,为卵巢癌诊断和判断预后的潜在分子指标.