DC、CIK、CD3AK细胞免疫治疗对恶性肿瘤患者凝血功能变化的影响

摘要

目的:探讨DC、CIK、CD3AK细胞免疫治疗前、后的晚期恶性肿瘤患者凝血功能、D-二聚体及血小板的变化.方法:选择DC、CIK、CD3AK细胞免疫治疗的61例晚期恶性肿瘤患者,在采集细胞前1天内及DC、CIK、CD3AK细胞免疫治疗后的3天内行凝血功能、D-二聚体及血小板的检测.比较DC、CIK、CD3AK细胞免疫治疗前、后的凝血功能、D-二聚体及血小板的差异.结果:DC、CIK、CD3AK细胞免疫治疗后D-二聚体、FDP均较前升高(P＜0.05),差异有统计学意义;PT、PT_INR较治疗前有所升高,但差异无统计学意义(P＞0.05).结论:DC、CIK、CD3AK细胞免疫治疗3天内D-二聚体及FDP水平升高,在一定程度上加重晚期肿瘤患者高凝状态或血栓形成的风险.%Objective:To explore the changes of coagulation,D-dimer and platelet after DC,CIK,CD3AK cell immunotherapy in advanced malignant tumor patients.Methods:All 61 cases of advanced malignant tumor patients were treated by DC,CIK,CD3AK cell immunotherapy,all the patients were tested for coagulation,D-dimer and platelet at one day before collecting cell and at three days after DC,CIK,CD3AK cell immunotherapy.Results:After DC,CIK,CD3AK cell immunotherapy,D-dimer and FDP increased (P ＜ 0.05),PT,PT_INR increased but no statisically difference (P ＞ 0.05).Conclusion:DC,CIK,CD3 AK cell immunotherapy can increase the level of D-dimer and FDP,to a certain extent,increase the risk of high blood coagulation state or thrombosis in advanced cancer patients.