CXCR5/CXCL13及ERK1在甲状腺乳头状癌中的表达及意义

摘要

目的:观察甲状腺乳头状癌及其转移灶中CXCR5/CXCL13及ERK1的表达,探讨其在肿瘤发生发展中的可能作用.方法:选取2014年1月到2016年5月在本院进行手术的110例甲状腺乳头状癌患者及同期手术的结节性甲状腺肿患者,采用免疫组化法检测CXCR5/CXCL13及ERK1在甲状腺乳头状癌及其转移灶 中的表达量.结果:CXCL13、CXCR5及ERK1在甲状腺乳头状癌及其转移淋巴结中的表达均高于正常腺体组织及结节性甲状腺肿患者(P＜0.05).CXCL13、CXCR5及ERK1蛋白在甲状腺乳头状癌中的表达与年龄和性别无关,与淋巴结转移呈正相关(P＜0.05).CXCR5/CXCL13蛋白的表达与ERK1呈正相关.结论:趋化因子CXCL13及其受体CXCR5在甲状腺乳头状癌发生发展及其淋巴结转移中发挥了重要作用,为临床甲状腺乳头状癌的诊断及靶向治疗提供一定的理论依据.%Objective:To investigate the expression of CXCR5/CXCL13 and ERK1,and to explore the possible role of occurrence and development in papillary thyroid carcinoma and the lymph node metastases.Methods:Totally 110 patients with papillary thyroid carcinoma and other 110 patients with nodular goiter who underwent surgery in our hospital from January 2014 to May 2016 were enrolled in this study.Immunohistochemistry was used to detect the ex-pression of CXCR5/CXCL13 and ERK1 in papillary thyroid carcinoma and lymph node metastases.Results:The ex-pressions of CXCL13,CXCR5 and ERK1 in papillary thyroid carcinoma and metastatic lymph nodes were significantly higher than those in normal glandular tissue and nodular goiter(P＜0.05).The expression of CXCL13,CXCR5 and ERK1 in papillary thyroid carcinoma was not related to age and gender,and positively correlated with lymph node me-tastasis(P＜0.05).The expression of CXCR5/CXCL13 protein was positively correlated with ERK1.Conclusion:The chemokine CXCL13 and its receptor CXCR5 play an important role in the development of papillary thyroid carci-noma and its lymph node metastasis,and provide a theoretical basis for the diagnosis and targeted therapy of papillary thyroid carcinoma.