卵巢癌肿瘤标志物的研究进展

摘要

卵巢癌(ovarian cancer,OC)是我国女性病死率最高的妇科肿瘤,而大部分卵巢癌患者在发病中晚期才能得到诊断,因此早期诊断卵巢癌对于疾病的治疗具有极其重要的价值.目前最常用早期诊断方式包括经阴道彩色多普勒超声、血清癌抗原125(cancer antigen,CA125)等检查方法,然而以上方法都尚存在局限性.近年来,许多研究者致力于寻找高敏感性、高特异性的肿瘤标志物,如:人附睾上皮分泌蛋白4(human epididymis,HE4)、共刺激分子B7同源体4(B7 homologous body 4,B7 -H4)、人溶血磷脂酸(lysophosphatidic acid,LPA)等,以提高卵巢癌诊断率.本文就卵巢癌相关的肿瘤标志物作一综述.%Ovarian cancer is the highest fatality gynecological tumor in China.Most patients with ovarian cancer can be dignosed in middle or later period,so early diagnosis has extremely important value for the treatment of ovarian cancer.Nowadays,the most commonly used clinical examination for ovarian cancer is transvaginal color doppler sonog-raphy and CA125.However,these methods still have limitations.In recent years,researchers committed to search for tumor markers of high sensitivity and specificity such as human epididymis,B7 homologous body 4,lysophosphatidic acid and so on,to improve the diagnostic rate of ovarian cancer.This paper reviews current tumor markers in relation to ovarian cancer.