目的:分析子宫内膜癌组织中雌孕激素受体蛋白在正常子宫内膜、非典型增生子宫内膜和子宫内膜癌组织中的表达特点,研究子宫内膜癌组织中雌孕激素受体蛋白表达与临床病理特征及治疗预后的相关性.方法:选取79例子宫内膜癌标本、48例正常子宫内膜标本和51例非典型增生子宫内膜标本作为回顾性分析标本,应用免疫组织化学方法对三种标本雌孕激素受体蛋白表达进行检测,对比分析雌孕激素受体蛋白在正常子宫内膜、非典型增生子宫内膜和子宫内膜癌组织中的表达差异,并研究子宫内膜癌组织中雌孕激素受体蛋白表达与临床病理特征及治疗预后的相关性.结果:子宫内膜癌组织中雌孕激素受体蛋白表现出高阳性率(43.04%),显著高于正常内膜组织中的阳性率(27.08%)和增生内膜组织中的阳性率(39.22%),差异具有统计学意义(P<0.05);G 1级子宫内膜癌患者的雌孕激素受体蛋白阳性表达率(21.16%)显著高于G2级、G3级子宫内膜癌阳性表达率(34.78%和30.77%),差异具有统计学意义(P<0.05);Ⅰ期手术病理子宫内膜癌患者的雌孕激素受体蛋白阳性表达率(51.52%)显著高于 Ⅱ、Ⅲ、Ⅳ期阳性表达率(37.50%、29.41%和46.15%),差异具有统计学意义(P<0.05);阳性表达患者的术后累积生存率(86.67%)显著高于阴性表达患者的术后累积生存率(71.05%),差异具有统计学意义(x2=1.556,P<0.05).结论:雌孕激素受体蛋白2级、过度表达在子宫内膜癌发生发展中起到一定的作用,可为子宫内膜癌患者治疗预后观察作参考.%Objective:To analyze the expression characteristics of estrogen and progesterone receptor protein in normal endometrium,atypical hyperplasia endometrium and endometrial carcinoma in endometrial carcinoma. To study the expression of estrogen and progesterone receptor in endometrial carcinoma correlation between protein expression and clinicopathological features and prognosis of treatment. Methods:79 cases of endometrial carcinoma specimens, 48 cases of normal endometrial specimens and 51 cases of atypical hyperplasia endometrial specimens were retrospec-tively analyzed. Immunohistochemical method was used to evaluate the expression of estrogen and progesterone recep-tor protein,and to compare the expression of estrogen and progesterone receptor protein in normal endometrium,atypi-cal hyperplasia endometrium and endometrial carcinoma,and to study the expression of estrogen and progesterone re-ceptor protein in endometrial carcinoma clinicopathological features and prognosis of treatment. Results:The positive rate of estrogen and progesterone receptor protein(56. 96%)in endometrial carcinoma was significantly higher(P <0. 05). Than that in normal endometrium(27. 08%)and positive rate in proliferative endometrium (39. 22%,P <0. 05). The positive expression rate of estrogen and progesterone receptor protein(21. 16%)in G 1 grade endometrial carcinoma was significantly higher than that in G2 and G3 grade endometrial carcinoma(P < 0. 05)(34. 78% and 30. 77%)indicated significantly different(P < 0. 05). The positive expression rate of estrogen and progesterone re-ceptor protein(51. 52%)was significantly higher in patients with endometrial carcinoma. The positive expression rates of estrogen and progesterone receptor protein(37. 50%,29. 41% and 46. 15%)in patients with endometrial carcino-ma indicated significantly different(P < 0. 05). The positive expression of estrogen and progesterone receptor in pa-tients with endometrial carcinoma. The cumulative survival rate(86. 67%)was significantly higher than that of nega-tive expression(71. 05%),and there was significant difference(x2 = 1. 556,P < 0. 05). Conclusion:Overexpression of estrogen and progesterone receptor protein plays an important role in the development of endometrial carcinoma, which can be used as a reference for the treatment of endometrial cancer.
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