肺炎衣原体感染与缺血性脑卒中及其亚型的相关性分析

摘要

Objective To detect the level of Chlamydia pneumoniae(Cpn)antibody in the plasma of patients with acute ische mic stroke(AIS) and investigate the correlation of AIS and Cpn infection. Methods CpnlgCCpnlgA and CpnlgM were de tected in 62 plasma samples of AIS and 48 that of healthy controls with ELISA. Results The positivity of CpnlgA in pa tients with AIS was higher than that in healthy controls (X2 =7. 24, P<0. 01). There was no difference in IgA or IgG posi tivity between LA and SA stroke subtypes(P＞0. 05). Numbers of patients positive for IgM were too small to analyze. Conclusion Cpn recent infection was related to AIS and might involve in the trigger and development of AIS.%目的 检测各种缺血性脑卒中(AIS)患者血浆中肺炎衣原体(Cpn)各种抗体水平,探讨AIS和Cpn感染的相关性.方法 收集62例AIS患者和48例健康对照者血浆,用ELISA方法检测CpnIgG,IgA和IgM水平.结果 AIS组CpnIgA阳性率为61.3%,明显高于健康对照组(33.3%)的阳性率(χ2=7.24,P<0.01),LA和SA两种亚型AIS患者间CpnIgA抗体阳性率分别为57.1%和55%,两者差异无统计学显著性意义(χ2=0.98,P>0.05);LA和SA两种亚型AIS患者间CpnIgG抗体阳性率分别为68.6%和50%,两者间差异无统计学显著性意义(χ2=0.1,P>0.05);CpnIgM抗体阳性病人和心源性AIS及不明原因AIS病人数量太少,不适合做统计分析.结论 Cpn新近感染与AIS相关,可能参与AIS疾病的发生发展过程.