胸腔积液中CEA,FDP和DD检测对良恶性胸腔积液鉴别的意义

摘要

Objective To investigate the significance of expressions of carcinoembryonic antigen(CEA),fibrinogen degrada-tion products(FDP)and D-dimer(DD)in the pleural effusion specimens for differential diagnosis between the benign and malignant pleural effusion.Methods 40 patients with benign pleural effusion patients and 30 patients with malignant pleural effusion were divided into benign or malignant group.The levels of CEA in pleural effusion was detected by electrochemilu-minescence,and FDP and DD were measured by turbidimetry.The value of diagnosis of three separate indicators and combine detection was compared by ROC analysis.Results The levels of CEA,FDP and DD in the pleural effusion specimens of ma-lignanat group were significantly higher than the benign group(t=2.523~3.889,all P<0.01).The sensitivity of combined detection of CEA,FDP and DD was 76.7%,and the rate of correct diagnosis was 82.9%.The sensitivity and diagnostic dffeiciency of combined detection were higher than separate indicators(χ2=1.036~3.324,all P<0.05).Conclusion Com-bined detection of CEA,FDP and DD is helpful to differential diagnosis of benign and malignant pleural effusion.%目的 探讨胸腔积液中癌胚抗原(CEA)、纤维蛋白原降解产物(FDP)和 D-二聚体(DD)的表达对良恶性胸腔积液鉴别诊断的意义.方法 选取陕西省人民医院收治的良性胸腔积液患者40例为良性组,恶性胸腔积液患者30例为恶性组.采用电化学发光免疫法检测两组胸腔积液中CEA的表达水平,胶乳免疫比浊法检测两组胸腔积液中 FDP和 DD的表达水平.通过 ROC分析比较上述三项指标单独和联合检测对良恶性胸腔积液鉴别诊断的价值.结果 恶性胸腔积液中CEA,FDP和DD水平均高于良性组,差异具有统计学意义(t=2.523~3.889,均P<0.01).CEA,FDP和 DD联合检测恶性胸腔积液的敏感度为76.7%,准确率为82.9%,均高于其中一项或两项联合检测(χ2=1.036~3.324,均 P<0.05).结论 胸腔积液中CEA,FDP和DD联合检测对良恶性胸腔积液的鉴别诊断具有重要意义.