三种肾小球滤过率预测公式在肾脏肿瘤患者肾功能评估中的应用

摘要

目的：：评价肾小球滤过率(GFR )预测公式在肾肿瘤患者肾功能评估中的应用价值。方法：选取2010年9月~2013年6月收治的肾肿瘤患者73例,以99 m Tc-DTPA 肾动态显像法测得的r GFR 为金标准,计算慢性肾脏病流行病学合作研究(CKD-EPI )公式、简化 MDRD 公式及中国改良简化 MDRD 公式的预测e GFR 与其相关性,及不同分割点时各公式诊断的敏感性。结果：三个公式的e GFR 值与r GFR 值有很好的相关性(相关系数分别为r ＝0.658,P ＝0.001；r ＝0.806,P ＝0.000；r ＝0.795,P ＝0.000)。当分别以90或60 ml •mi n －1•1.73 m －2为诊断分割点时,受试者工作特征曲线(ROC )曲线下面积比较差异无统计学意义。结论：3种公式均具有较好的预测肾脏肿瘤患者 GFR 的能力,可作为有效的肾功能评价的指标。%Objective :To eval uate the applicability of CKD-EPI equati on ,si mplified MDRD equti on and refitted MDRD equati on to Chi nese to predicate gl o merular filtrati on rate (GFR)i n Chi nese patient with renal tu mor .Meth-ods :A total of 73 renal tu mor patients were enrolled .9 9 m Tc-DTPA-GFR was used as gol den standard .The val ue of esti mated GFR gai ned through CKD-EPI equati on ,si mplified MDRD equti on and refitted MDRD equati on to Chi nese were co mpared to r GFR .Results :There were si gnificant correlati ons a mong e GFR and r GFR respecti vel y (r =0.658 , P =0.001 ;r =0.806 ,P =0.000 ;r =0.795 ,P =0.000 ).There were no si gnificant difference of the area under ROC curve bet ween the t wo poi nts with 90 or 60 ml •mi n -1 •1.73 m -2 as the diagnostic cut-off poi nt .Conclusions :All of these three equati ons coul d be used as an efficient tool to eval uate renal functi on of renal tu mor patients .