1，3-丙二醇（1，3-PD）是一种重要的化工原料，广泛应用于医药、化工、食品及化妆品等行业，同时1，3-PD是合成聚对苯二甲酸丙二酯（PTT）的重要单体，市场需求量逐年增多。基于生态友好型、生产安全和可持续发展的要求，利用微生物转化可再生资源来生产1，3-PD受到了人们的广泛重视。综述了微生物发酵法生产1，3-PD的菌株、代谢途径、发酵和下游分离工艺及其新进展，并对工业生产中利用生物技术生产1，3-PD的未来前景和挑战进行了探讨。%1,3-Propanediol (1,3-PD) is an important raw material which is widely used in pharmaceutical , chemi-cal, food and cosmetic industries .As a promising monomer for the synthesis of poly ( trimethylene terephthalate ) ( PTT) , its market demand is increasing linearly .Based on the demand of safe and eco-friendly production process and sustainable development , microbial conversion of renewable resources into 1,3-PD has been paid more and more attention.In this paper, we will discuss 1,3-PD producers with relation to their metabolism and fermentation technolo-gies, as well as the downstream processing of biologically produced 1,3-PD.The prospects and challenges for the in-dustrial production of bio-based 1,3-PD are also presented.
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