免疫抑制剂治疗对儿童疫苗诱导的免疫保护性的影响及其相关机制

摘要

疫苗是目前公认的预防传染病的有效手段,接种疫苗可极大降低人群传染病的发病率和病死率.随着现代医学的进展,接受免疫抑制剂治疗肿瘤、器官移植、造血干细胞移植及慢性病的患儿生存率有了很大提高,但免疫抑制剂的使用会影响疫苗诱导的免疫保护效果及儿童时期疫苗接种的安全性,使这部分免疫低下的特殊儿童成为疫苗可预防疾病的高危易感人群.本文综述了免疫抑制剂对儿童疫苗免疫保护性的影响及其相关机制.%Vaccine is the most effective tool to prevent infectious diseases and to improve the public health.With the advance of modern medicine, the survival rate among pediatric cancer and chronic disease patients treated with immunosuppressive medication has improved greatly.However, immunosuppressant therapy has impact on vaccine-induced immune protection in children.As a result, the immunosuppressive children are in a high risk of developing vaccine-preventable diseases.This article is to review the clinical impact and mechanism of immunosuppressant therapy on vaccine-induced immune protection in children.