目的：探索酶法测定糖化白蛋白（GA ）在妊娠期糖尿病早期诊断、疗效监测中的作用。方法：对20例临床高度发生妊娠期糖尿病倾向的孕妇进行定期糖化白蛋白和糖化血红蛋白的检测。对10例已诊断为妊娠糖尿病进行口服瑞格列奈治疗的孕妇进行定期糖化白蛋白和糖化血红蛋白（HbA1c）的检测以判断药物的疗效。结果：20例有发展为妊娠糖尿病倾向的孕妇糖化白蛋白异常出现的平均时间为妊娠（150±15．8）d ，糖化血红蛋白异常出现的平均时间为（210±16．2）d。10例口服瑞格列奈治疗的孕妇糖化白蛋白明显降低的时间为服药后第7周，而糖化血红蛋白明显降低的时间为服药第10周。结论：糖化白蛋白能较早诊断妊娠糖尿病，也能更早预测降糖药物治疗效，故糖化白蛋白检测较适合妊娠期糖尿病的诊断和疗效评估。%Objective :To discuss the significance of enzymatic method for glycoated albumin in diagnose pregnant dia-betes and to assess medical effect .Methods :20 pregnant women who were apt to suffer from diabetes Mutulis were asked to take GA and HbA1c test on time .10 cases diagnosed DM were asked to take GA and HbA1c test every two weeks after treated with repaglinide .Results:The time when the mean value of glycoated albumin level is higher than the upper limit is (150 ± 15 .8) days ,while that of HbA1c is (210 ± 16 .2) days .About seven weeks later treated by repaglinide ,the GA is lower than the upper limit ,while HbA1c lower is ten weeks later .Conclusion:GA is a good indi-cator to early diagnose GDM and predict the medical effect .
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