HER2蛋白在胃癌组织中的表达与临床病理学参数的相关性研究

摘要

目的：比较 HER2蛋白在胃腺癌组织的表达与患者的年龄、性别、部位、分化、新的WHO分类以及TNM 分期等临床病理学参数的相关性。方法：使用免疫组织化学（IHC）方法检测胃腺癌患者中 HER2蛋白的表达，以修订后HercepTest评分标准进行评分。χ2检验分析HER2蛋白在胃腺癌组织中的表达与临床病理学参数的相关性。结果：590例患者中位年龄58．6岁，男女比例1．91∶1，其中Ⅲ＋Ⅳ期胃腺癌患者461例。使用修订后 HercepTest评分标本准进行判读为HER2（3＋）阳性表达患者共51例（51/590），其中Ⅲ＋Ⅳ期胃腺癌中的HER2（3＋）阳性表达患者45例。 HER2蛋白阳性过表达与肿瘤最大长径、分化、新的WHO分型、TNM 分期相关，而与患者的年龄、性别、肿瘤部位、浸润深度无相关。结论：HER2蛋白在胃腺癌组织中的表达与胃腺癌的肿瘤分化、新的WHO分型、TNM 分期相关，有可能作为判断胃癌生物学行为的指标及为靶向治疗提供依据。%Objective :To investigate the expression of HER2 protein and their association with clinicopathology fea-tures in gastric adenocarcinoma .Methods :The HER2 status was evaluated using immunohistochemistry .The modified Hercep Test scoring criterion was used to assess HER2 protein expression .The association between HER2 expression and clinicopathological features was analyzed by χ2 test .Results:The median age of patients was 58 .6 years ,and the male to female ratio was 1 .91∶1 ,Positive expression of HER2 protein (3+ ) was found in 51(51/590)cases of gastric adenocarcinoma by the modified HercepTest scoring criterion ,and in 45(45/590) gastric adenocarcinoma of the Ⅲ andⅣ stage ,There was significantly positive association between HER2 over-expression and tumor differentiation and di-ameter ,New WHO classification ,the TMN stage .NO significang association was observed between HER2 protein ex-pression and patients’age ,gender ,tumor location and invasion depth .Conclusion:There was significantly positive asso-ciation between HER2 expression status and tumor differentiation ,new WHO classification ,the TMN stage in gastric adenocarcinoma ,it maybe of helpful to judge the biological behavior ,guide the treatment for patients .