目的：通过观察黄体酮和绒毛膜促性腺激素（HCG）对先兆流产的治疗效果，探讨两种药物对妊娠结局的影响。方法：选取门诊诊断为早期先兆流产的孕妇279例，分为三组，A 组给予黄体酮20mg 肌内注射，1次/d ；B 组给予HCG 2000IU 肌内注射，1次/d ；C 组为对照组，仅予卧床休息，阴道出血停止后维持用药1周。追踪随访观察对象的妊娠成功率、足月分娩率、流产率、早产率、新生儿畸形率、新生儿并发症、新生儿体重等指标。结果：A 组与 B 组在妊娠成功率及流产率方面差异无统计学意义，但是同 C 组比较差异均有统计学意义。 A 组、B 组新生儿体重高于 C 组，差异有统计学意义。三组新生儿畸形率、新生儿并发症比较，差异均无统计学意义。结论：黄体酮与 HCG 均能改善先兆流产患者的预后，且对母儿无不良影响。%Objective :To observe the efficacy of Progesterone and Chorionic Gonadotrophin in the treatment of threat-ened abortion ,and approach the effective of two kinds of medicine in the treatment of pregnancy outcome .Methods :The patients was diagnosed as threatened abortion in early pregnant women 279 cases ,divided into 3 groups ,intramuscular injection of Progesterone 20mg ,1 times/day for group A ;intramuscular injection of HCG 2 000IU ,1 times/day for group B ;group C was control group ,only to be bed rest .The deadline for the treatment was vaginal bleeding 1 week af-ter the cessation of maintenance medication .Followed up the success rate of pregnancy observed objects ,full-term de-livery rate ,miscarriage rate ,premature delivery rate ,neonatal malformation rate ,neonatal complications ,neonatal weight and other indicators .Results :The successful pregnancy rate and abortion rate were not significance of difference between group A and group B ,but compared with the C group ,there were significant differences .The neonatal weight of group A and group B were heavier than group C ,the difference was statistically significant .The rate of neonatal malformations and neonatal complications in three groups ,there were not statistically significant .Conclusion :Proges-terone and HCG can improve the prognosis of threatened abortion ,and no adverse effects on mother and child .
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